Foster Warren G
Centre for Reproductive Care, Hamilton Health Sciences, and Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada.
J Toxicol Environ Health B Crit Rev. 2008 Mar;11(3-4):177-87. doi: 10.1080/10937400701873456.
Endometriosis is a common gynecologic disease of unknown etiology affecting approximately 10-15% of women of reproductive age and 50% of infertile women. Estrogen dependence and immune modulation are established features of endometriosis but do not adequately explain the cause of this disorder. In recent years evidence indicated that exposure to environmental toxicants possessing estrogenic activity resulted in endometriosis. However, scant hospital-based case-control studies yielded inconsistent findings and thus did not provide a compelling argument for or against an association between environmental toxicant exposure and endometriosis. Results of animal studies and cell culture experiments, however, suggested that it is biologically plausible for environmental toxicants to affect the pathobiology of endometriosis. In this article, the literature linking environmental toxicants with endometriosis was reviewed and the link with endocrine toxicants discussed.
子宫内膜异位症是一种病因不明的常见妇科疾病，影响约10%-15%的育龄妇女和50%的不孕妇女。雌激素依赖性和免疫调节是子宫内膜异位症的既定特征，但并不能充分解释这种疾病的病因。近年来，有证据表明，接触具有雌激素活性的环境毒物会导致子宫内膜异位症。然而，为数不多的基于医院的病例对照研究结果并不一致，因此并未提供支持或反对环境毒物暴露与子宫内膜异位症之间关联的有力论据。然而，动物研究和细胞培养实验的结果表明，环境毒物影响子宫内膜异位症的病理生物学在生物学上是合理的。在本文中，回顾了将环境毒物与子宫内膜异位症联系起来的文献，并讨论了与内分泌毒物的联系。
