内分泌干扰化学物质对体外受精中卵母细胞/胚胎及临床结局的影响。
The impact of endocrine disruptor chemicals on oocyte/embryo and clinical outcomes in IVF.
作者信息
Cabry Rosalie, Merviel Philippe, Madkour Aicha, Lefranc Elodie, Scheffler Florence, Desailloud Rachel, Bach Véronique, Benkhalifa Moncef
机构信息
Amiens University, Amiens, Haut-de-France, France.
Brest University, Brest, Bretagne, France.
出版信息
Endocr Connect. 2020 Jun;9(6):R134-R142. doi: 10.1530/EC-20-0135.
Abstract
The negative impact of endocrine-disrupting pesticides on human fertility is now a key issue in reproductive health. There are much fewer literature data about the impact of pesticide exposure on women than on men and very few studies of women participating in an in vitro fertilization (IVF) programme. In the present review, we found that (1) various pesticides with an endocrine-disrupting action are associated with poor oocyte maturation and competency, embryonic defects and poor IVF outcomes, and (2) some pesticide compounds are linked to specific causes of female infertility, such as premature ovarian insufficiency, polycystic ovarian syndrome, and endometriosis. IVF participants living in agricultural regions should be informed about the fertility decline, low ongoing pregnancy rates, and elevated risk of miscarriage associated with exposure to high doses of pesticides.
摘要
内分泌干扰性农药对人类生育能力的负面影响如今已成为生殖健康领域的一个关键问题。关于农药暴露对女性影响的文献数据比男性少得多，而且很少有针对参与体外受精（IVF）项目女性的研究。在本综述中，我们发现：（1）具有内分泌干扰作用的各种农药与卵母细胞成熟度和能力差、胚胎缺陷以及体外受精结果不佳有关；（2）一些农药化合物与女性不孕的特定原因有关，如卵巢早衰、多囊卵巢综合征和子宫内膜异位症。生活在农业地区的体外受精参与者应被告知，接触高剂量农药会导致生育能力下降、持续妊娠率低以及流产风险升高。
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本文引用的文献
1
Selected persistent organic pollutants associated with the risk of primary ovarian insufficiency in women.与女性原发性卵巢功能不全风险相关的选定持久性有机污染物。
Environ Int. 2019 Aug;129:51-58. doi: 10.1016/j.envint.2019.05.023. Epub 2019 May 17.
2
Deltamethrin exposure induces oxidative stress and affects meiotic maturation in mouse oocyte.溴氰菊酯暴露诱导氧化应激并影响小鼠卵母细胞的减数分裂成熟。
Chemosphere. 2019 May;223:704-713. doi: 10.1016/j.chemosphere.2019.02.092. Epub 2019 Feb 15.
3
Effects of environmental contaminants on fertility and reproductive health.环境污染物对生育力和生殖健康的影响。
J Environ Sci (China). 2019 Mar;77:210-217. doi: 10.1016/j.jes.2018.07.015. Epub 2018 Aug 22.
4
Beta-cypermethrin exposure affects female reproduction by enhancing oxidative stress in mice uterine tissue.β-氯氰菊酯暴露通过增强小鼠子宫组织的氧化应激来影响雌性生殖。
Regul Toxicol Pharmacol. 2018 Oct;98:284-290. doi: 10.1016/j.yrtph.2018.08.011. Epub 2018 Aug 20.
5
Isolated hypospadias: The impact of prenatal exposure to pesticides, as determined by meconium analysis.孤立性尿道下裂：通过对胎粪进行分析，确定与产前暴露于农药之间的关系。
Environ Int. 2018 Oct;119:20-25. doi: 10.1016/j.envint.2018.06.002. Epub 2018 Jun 18.
6
Fertility and infertility: Definition and epidemiology.生育与不孕：定义及流行病学
Clin Biochem. 2018 Dec;62:2-10. doi: 10.1016/j.clinbiochem.2018.03.012. Epub 2018 Mar 16.
7
Pyrethroid Pesticide Exposure and Risk of Primary Ovarian Insufficiency in Chinese Women.拟除虫菊酯类农药暴露与中国女性原发性卵巢功能不全风险。
Environ Sci Technol. 2018 Mar 6;52(5):3240-3248. doi: 10.1021/acs.est.7b06689. Epub 2018 Feb 22.
8
The effect of follicullar fluid pesticides and polychlorinated biphenyls concentrations on intracytoplasmic sperm injection (ICSI) embryological and clinical outcome.卵泡液中农药和多氯联苯浓度对卵胞浆内单精子注射（ICSI）胚胎学及临床结局的影响。
Eur J Obstet Gynecol Reprod Biol. 2018 Jan;220:39-43. doi: 10.1016/j.ejogrb.2017.11.003. Epub 2017 Nov 16.
9
Association Between Pesticide Residue Intake From Consumption of Fruits and Vegetables and Pregnancy Outcomes Among Women Undergoing Infertility Treatment With Assisted Reproductive Technology.食用水果和蔬菜摄入的农药残留与接受辅助生殖技术治疗不孕的女性妊娠结局的关系。
JAMA Intern Med. 2018 Jan 1;178(1):17-26. doi: 10.1001/jamainternmed.2017.5038.
10
The pesticide Lindane induces dose-dependent damage to granulosa cells in an in vitro culture.农药林丹在体外培养中会诱导颗粒细胞产生剂量依赖性损伤。
Reprod Biol. 2017 Dec;17(4):349-356. doi: 10.1016/j.repbio.2017.09.008. Epub 2017 Oct 10.
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