Kobayashi S, Terayama K
Orthopaedic Surgery Department, Shinshu University Medical School, Matsumoto, Japan.
Rev Chir Orthop Reparatrice Appar Mot. 1991;77(5):362-5.
The combination of endogenous hypercortisolism and avascular necrosis is rare. A 53-year-old woman suffering from Cushing's disease, whose presenting symptom was hip-joint pain due to osteoarthritis secondary to avascular necrosis of the femoral head is described. About 6 years passed between a remarkable increase in weight and the onset of hip-joint pain. The hip joint was progressively destroyed, and total hip replacement was necessary 7 years after the onset of pain. This case report, as well as several previous reports, shows that avascular necrosis of bone may appear as a rare presenting manifestation of Cushing's disease.
内源性皮质醇增多症与缺血性坏死并存的情况较为罕见。本文描述了一名53岁患库欣病的女性，其主要症状是由股骨头缺血性坏死继发骨关节炎引起的髋关节疼痛。体重显著增加与髋关节疼痛发作之间间隔了约6年。髋关节逐渐遭到破坏，疼痛发作7年后需要进行全髋关节置换。本病例报告以及先前的几份报告均表明，骨缺血性坏死可能是库欣病一种罕见的表现形式。
