[Coxarthrosis secondary to ischemic necrosis of the femoral head in Cushing's disease].

The combination of endogenous hypercortisolism and avascular necrosis is rare. A 53-year-old woman suffering from Cushing's disease, whose presenting symptom was hip-joint pain due to osteoarthritis secondary to avascular necrosis of the femoral head is described. About 6 years passed between a remarkable increase in weight and the onset of hip-joint pain. The hip joint was progressively destroyed, and total hip replacement was necessary 7 years after the onset of pain. This case report, as well as several previous reports, shows that avascular necrosis of bone may appear as a rare presenting manifestation of Cushing's disease.