Stockholm Gerontology Research Centre & Department of Geriatric Medicine, Karolinska Institute, Stockholm, Sweden.
Clin Drug Investig. 1997;13(2):105-17. doi: 10.2165/00044011-199713020-00007.
In a cross-sectional study, we have investigated the prevalence of self-reported symptoms and their association with medicinal drug use in elderly people. Data from the Kungsholmen Project were used, a population-based study of elderly people aged 75 years and over in Stockholm, Sweden. The study sample comprised 1800 persons. Information on the occurrence of 22 different symptoms and the actual drug use was obtained at interviews with the participants. The relation of symptoms to age, gender and housing, and their association with drug use was analysed using logistic regression. The most commonly reported symptoms were pain and tiredness. In general, symptoms were more common in women and at higher ages. Many of the associations between symptoms and drug use reflected established treatments. However, some were suggestive of inappropriate treatment or dosage; for example, the association between tiredness and the use of anxiolytics and hypnotics-sedatives.
在一项横断面研究中，我们调查了老年人自述症状的患病率及其与药物使用的关系。研究数据来自斯德哥尔摩 Kungsholmen 项目，该项目是瑞典斯德哥尔摩市一项针对 75 岁及以上老年人的基于人群的研究。研究样本包括 1800 人。通过对参与者的访谈，获得了 22 种不同症状的发生情况和实际药物使用情况。使用逻辑回归分析症状与年龄、性别和住房的关系及其与药物使用的关联。报告最多的症状是疼痛和疲劳。一般来说，女性和年龄较大的人更容易出现症状。许多症状与药物使用之间的关联反映了既定的治疗方法。然而，有些则表明治疗或剂量不当；例如，疲劳与使用抗焦虑药和催眠镇静药之间的关联。
