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高龄人群的睡眠问题:药物使用及临床关联

Sleep problems in a very old population: drug use and clinical correlates.

作者信息

Giron Maria Stella T, Forsell Yvonne, Bernsten Cecilia, Thorslund Mats, Winblad Bengt, Fastbom Johan

机构信息

NEUROTEC, Karolinska Institute, Stockholm, Sweden.

出版信息

J Gerontol A Biol Sci Med Sci. 2002 Apr;57(4):M236-40. doi: 10.1093/gerona/57.4.m236.

DOI:10.1093/gerona/57.4.m236
PMID:11909889
Abstract

BACKGROUND

Complaints of disturbed or dissatisfied sleep are common among older people. This study aimed to evaluate the prevalence of sleep problems in very old persons and its relation to physical and mental health and drug use.

METHODS

This is a cross-sectional analysis of sleep problems in a population of old persons living in Stockholm, Sweden. There were 641 subjects aged 81+ years; 77.8% were women, 91.4% were noninstitutionalized, and 68.6% lived alone. All persons underwent a comprehensive medical and psychiatric interview and examination. Sleep problems were assessed using the Clinical Psychopathological Rating Scale (CPRS). Covariates included chronic medical conditions, depression, dementia, pain, self-rated health, activities of daily living, use of hypnotics-sedatives, use of other psychotropic drugs, and use of nonpsychotropic drugs.

RESULTS

More than one third of subjects were identified with sleep problems. They were more common among women and persons using a higher number of drugs. Poor self-rated health, depression, and pain were related to the presence of sleep problems. Among persons with sleep problems and depression, only 19.2% used antidepressants, and 46.2% used hypnotics-sedatives. Among persons with sleep problems and pain, 63.2% used analgesics, and 47.0% used hypnotics-sedatives. One or more chronic diseases, use of hypnotics-sedatives, use of other psychotropic drugs, and use of nonpsychotropic drugs were also related to sleep problems. After multivariate analysis, factors significantly related to sleep problems were female gender, depression, pain, and hypnotic-sedative use.

CONCLUSIONS

Sleep problems were common in this very old population. These results suggest the importance of carefully assessing an older person's complaints to accurately diagnose and effectively treat sleep problems.

摘要

背景

睡眠受到干扰或不满意的抱怨在老年人中很常见。本研究旨在评估高龄老人睡眠问题的患病率及其与身心健康和药物使用的关系。

方法

这是一项对居住在瑞典斯德哥尔摩的老年人群睡眠问题的横断面分析。有641名年龄在81岁及以上的受试者;77.8%为女性,91.4%未入住机构,68.6%独自生活。所有受试者都接受了全面的医学和精神科访谈及检查。使用临床精神病理评定量表(CPRS)评估睡眠问题。协变量包括慢性疾病、抑郁、痴呆、疼痛、自评健康状况、日常生活活动能力、催眠镇静药的使用、其他精神药物的使用以及非精神药物的使用。

结果

超过三分之一的受试者被确定存在睡眠问题。这些问题在女性和使用较多药物的人群中更为常见。自评健康状况差、抑郁和疼痛与睡眠问题的存在有关。在有睡眠问题和抑郁的人群中,只有19.2%使用抗抑郁药,46.2%使用催眠镇静药。在有睡眠问题和疼痛的人群中,63.2%使用镇痛药,47.0%使用催眠镇静药。一种或多种慢性疾病、催眠镇静药的使用、其他精神药物的使用以及非精神药物的使用也与睡眠问题有关。多变量分析后,与睡眠问题显著相关的因素是女性、抑郁、疼痛和催眠镇静药的使用。

结论

睡眠问题在这个高龄人群中很常见。这些结果表明仔细评估老年人的抱怨对于准确诊断和有效治疗睡眠问题的重要性。

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