荣耀如此消逝：告别表皮过渡放大细胞？

Sic transit gloria: farewell to the epidermal transit amplifying cell?

作者信息

Jones Philip H, Simons Benjamin D, Watt Fiona M

机构信息

MRC Cancer Cell Unit, Hutchison-MRC Research Centre, Cambridge CB2 0XZ, UK.

出版信息

Cell Stem Cell. 2007 Oct 11;1(4):371-81. doi: 10.1016/j.stem.2007.09.014.

DOI:10.1016/j.stem.2007.09.014

PMID:18371376

Abstract

For the past 30 years, the prevailing model of epidermal homeostasis has been that epidermal stem cells give rise to transit amplifying cells, which undergo a limited number of cell divisions before initiating terminal differentiation. Recent studies challenge the existence of a transit amplifying cell compartment and suggest a new paradigm for epidermal homeostasis.

摘要

在过去30年里，表皮稳态的主流模型一直是表皮干细胞产生短暂增殖细胞，这些细胞在开始终末分化之前经历有限次数的细胞分裂。最近的研究对短暂增殖细胞区室的存在提出了质疑，并提出了表皮稳态的新范式。