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编码高亲和力IgG受体的人类基因启动子的特性：γ干扰素介导的转录诱导是通过常见的DNA反应元件实现的。

Characterization of the promoter of the human gene encoding the high-affinity IgG receptor: transcriptional induction by gamma-interferon is mediated through common DNA response elements.

作者信息

Pearse R N, Feinman R, Ravetch J V

机构信息

DeWitt Wallace Research Laboratory, Division of Molecular Biology, Sloan-Kettering Institute, New York, NY 10021.

出版信息

Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11305-9. doi: 10.1073/pnas.88.24.11305.

DOI:10.1073/pnas.88.24.11305
PMID:1837149
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC53123/
Abstract

Expression of the high-affinity receptor for IgG (Fc gamma RI) is restricted to cells of myeloid lineage and is induced by gamma-interferon (IFN-gamma) but not by IFN-alpha/beta. The organization of the human Fc gamma RI gene has been determined and the DNA elements governing its cell type-restricted transcription and IFN-gamma induction are reported here. A 39-nucleotide sequence (IFN-gamma response region, or GRR) is defined that is both necessary and sufficient for IFN-gamma inducibility. Sequence analysis of the GRR reveals the presence of promoter elements initially defined for the major histocompatibility complex class II genes: i.e., X, H, and gamma-IRE sequences. Comparison of a number of genes whose expression is induced selectively by IFN-gamma indicates that the presence of these elements is a general feature of IFN-gamma-responsive genes. Our studies suggest that the combination of X, H, and gamma-IRE elements is a common motif in the pathway of transcriptional induction by this lymphokine.

摘要

IgG高亲和力受体（FcγRI）的表达仅限于髓系谱系细胞，由γ干扰素（IFN-γ）诱导，而不由IFN-α/β诱导。本文确定了人类FcγRI基因的结构，并报道了调控其细胞类型限制转录和IFN-γ诱导的DNA元件。定义了一个39个核苷酸的序列（IFN-γ反应区，或GRR），它对于IFN-γ诱导是必需且充分的。GRR的序列分析揭示了最初为主要组织相容性复合体II类基因定义的启动子元件的存在，即X序列、H序列和γ-IRE序列。对一些由IFN-γ选择性诱导表达的基因的比较表明，这些元件的存在是IFN-γ反应性基因的一个普遍特征。我们的研究表明，X、H和γ-IRE元件的组合是这种淋巴因子转录诱导途径中的一个共同基序。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b11/53123/af9aee96eabf/pnas01074-0337-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b11/53123/b9a6a73aa295/pnas01074-0336-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b11/53123/a2e50f2e8b13/pnas01074-0336-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b11/53123/97bd7e457511/pnas01074-0336-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b11/53123/0622a49bbddd/pnas01074-0337-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b11/53123/af9aee96eabf/pnas01074-0337-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b11/53123/b9a6a73aa295/pnas01074-0336-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b11/53123/a2e50f2e8b13/pnas01074-0336-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b11/53123/97bd7e457511/pnas01074-0336-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b11/53123/0622a49bbddd/pnas01074-0337-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b11/53123/af9aee96eabf/pnas01074-0337-b.jpg

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1
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2
A catalogue of splice junction sequences.剪接连接序列目录。
Nucleic Acids Res. 1982 Jan 22;10(2):459-72. doi: 10.1093/nar/10.2.459.
3
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Blood. 2020 Oct 29;136(18):2065-2079. doi: 10.1182/blood.2020005571.
4
Interferon-Independent Innate Responses to Cytomegalovirus.巨细胞病毒的干扰素非依赖型先天免疫反应
Front Immunol. 2019 Dec 11;10:2751. doi: 10.3389/fimmu.2019.02751. eCollection 2019.
5
Transcriptome analyses of Atlantic salmon muscle genes induced by a DNA vaccine against salmonid alphavirus, the causative agent of salmon pancreas disease (PD).大西洋三文鱼肌肉基因转录组分析，该基因被用于对抗鲑鱼传染性胰腺坏死病毒（IPNV）的 DNA 疫苗，IPNV 是导致三文鱼胰腺坏死病（PD）的病原体。
PLoS One. 2018 Oct 1;13(10):e0204924. doi: 10.1371/journal.pone.0204924. eCollection 2018.
6
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BMC Infect Dis. 2018 May 15;18(1):220. doi: 10.1186/s12879-018-3127-4.
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Coexistence of gain-of-function JAK2 germ line mutations with JAK2V617F in polycythemia vera.真性红细胞增多症中功能获得性JAK2种系突变与JAK2V617F的共存。
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