Abbassy Mona Aly, Watari Ippei, Soma Kunimichi
Orthodontic Science, Department of Orofacial Development and Function, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University, 1-5-45, Yushima, Tokyo 113-8549, Japan.
Arch Oral Biol. 2008 Sep;53(9):819-25. doi: 10.1016/j.archoralbio.2008.02.008. Epub 2008 Mar 26.
The goal of this study was to assess the effect of type 1 diabetes mellitus (T1DM) on the craniofacial growth and skeletal maturation using the STZ-DM rat model.
Experimental T1DM was induced in 3-week-old male Wistar rats by a single dose of 60 mg/kg body weight of streptozotocin (STZ). Lateral and dorsoventral X-rays of the head were taken at the age of 7 weeks. The X-rays were scanned, digitised and selected linear distances were measured and analysed statistically.
In STZ-DM statistical analysis of results revealed a reduction in growth of most of the linear measurements in the neurocranium and mandible by X-ray analysis, and all measurements were significantly lower in viscerocranium.
Uncontrolled T1DM reduces craniofacial growth, resulting in retardation of skeletal development.
本研究的目的是使用链脲佐菌素诱导的糖尿病（STZ-DM）大鼠模型评估1型糖尿病（T1DM）对颅面生长和骨骼成熟的影响。
通过单次腹腔注射60mg/kg体重的链脲佐菌素（STZ）诱导3周龄雄性Wistar大鼠患实验性T1DM。在7周龄时拍摄头部的侧位和背腹位X线片。对X线片进行扫描、数字化处理，并测量选定的线性距离，然后进行统计学分析。
通过X线分析对STZ-DM结果进行统计学分析发现，神经颅骨和下颌骨的大多数线性测量值生长减少，面颅骨的所有测量值均显著降低。
未控制的T1DM会减少颅面生长，导致骨骼发育迟缓。
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