Park Byong-Gon, Shin Woon-Seob, Um Yumi, Cho Sungsik, Park Gab-Man, Yeon Dong-Soo, Kwon Seong-Chun, Ham Jungyeob, Choi Byoung Wook, Lee Seokjoon
College of Medicine, Kwandong University, Gangneung, Gangwon 210-701, Republic of Korea.
Bioorg Med Chem Lett. 2008 Apr 15;18(8):2624-7. doi: 10.1016/j.bmcl.2008.03.034. Epub 2008 Mar 14.
Sargahydroquinoic acid (2), a major active constituent of Sargassum micracanthum collected from the coast of the East Sea in Korea, showed a selective vasodilatation effect on the basilar arteries of rabbits. Therefore, treatment with sargahydroquinoic acid may selectively accelerate cerebral blood flow through dilatation of the basilar artery without lowering systemic blood pressure.
马尾藻氢醌酸(2)是从韩国东海沿岸采集的小刺马尾藻的一种主要活性成分,对兔基底动脉显示出选择性血管舒张作用。因此,用马尾藻氢醌酸治疗可通过扩张基底动脉选择性地加速脑血流,而不会降低全身血压。