Gharib Ahmed M, Ho Vincent B, Rosing Douglas R, Herzka Daniel A, Stuber Matthias, Arai Andrew E, Pettigrew Roderic I
Department of Diagnostic Radiology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Radiology. 2008 Apr;247(1):220-7. doi: 10.1148/radiol.2471070274.
The purpose of this study was to prospectively use a whole-heart three-dimensional (3D) coronary magnetic resonance (MR) angiography technique specifically adapted for use at 3 T and a parallel imaging technique (sensitivity encoding) to evaluate coronary arterial anomalies and variants (CAAV). This HIPAA-compliant study was approved by the local institutional review board, and informed consent was obtained from all participants. Twenty-two participants (11 men, 11 women; age range, 18-62 years) were included. Ten participants were healthy volunteers, whereas 12 participants were patients suspected of having CAAV. Coronary MR angiography was performed with a 3-T MR imager. A 3D free-breathing navigator-gated and vector electrocardiographically-gated segmented k-space gradient-echo sequence with adiabatic T2 preparation pulse and parallel imaging (sensitivity encoding) was used. Whole-heart acquisitions (repetition time msec/echo time msec, 4/1.35; 20 degrees flip angle; 1 x 1 x 2-mm acquired voxel size) lasted 10-12 minutes. Mean examination time was 41 minutes +/- 14 (standard deviation). Findings included aneurysms, ectasia, arteriovenous fistulas, and anomalous origins. The 3D whole-heart acquisitions developed for use with 3 T are feasible for use in the assessment of CAAV.
本研究的目的是前瞻性地使用一种专门适用于3T的全心三维(3D)冠状动脉磁共振(MR)血管造影技术以及一种并行成像技术(敏感性编码)来评估冠状动脉异常和变异(CAAV)。这项符合健康保险流通与责任法案(HIPAA)的研究获得了当地机构审查委员会的批准,并获得了所有参与者的知情同意。纳入了22名参与者(11名男性,11名女性;年龄范围18 - 62岁)。10名参与者为健康志愿者,而12名参与者为疑似患有CAAV的患者。使用3T MR成像仪进行冠状动脉MR血管造影。采用了一种具有绝热T2准备脉冲和并行成像(敏感性编码)的3D自由呼吸导航门控和矢量心电图门控分段k空间梯度回波序列。全心采集(重复时间毫秒/回波时间毫秒,4/1.35;翻转角20度;采集体素大小1×1×2毫米)持续10 - 12分钟。平均检查时间为41分钟±14(标准差)。发现包括动脉瘤、扩张、动静脉瘘和异常起源。为3T开发的3D全心采集可用于评估CAAV。