Khan Fary, Pallant Julie F, Turner-Stokes Lynn
Department of Rehabilitation Medicine, University of Melbourne, and Royal Melbourne Hospital, Melbourne VIC, Australia.
Arch Phys Med Rehabil. 2008 Apr;89(4):652-9. doi: 10.1016/j.apmr.2007.09.049.
To use goal attainment scaling (GAS) to measure clinically important functional change in persons with multiple sclerosis (MS) and to assess its responsiveness compared with standard measures used to evaluate progress in rehabilitation.
Prospective, observational cohort study.
Tertiary inpatient rehabilitation unit in Victoria, Australia.
Consecutive sample of 24 persons with MS admitted for comprehensive rehabilitation program. The male-to-female ratio was 10:14, and the mean age +/- standard deviation was 52.0+/-8.3 years (range, 37-62y). Over half (n=14 [58.3%]) had secondary progressive MS.
Not applicable.
GAS scores were calculated for 5 to 10 priority goals set prospectively by each patient in agreement with the multidisciplinary treating team and compared with standard outcome measures-the FIM instrument and Barthel Index-rated on admission and discharge from the program. Patients were categorized into responders and nonresponders based on an overall clinical global impression.
Of 203 selected goals, 167 were achieved at the predicted level. GAS recorded outcomes for 105 individualized goals not measured by the FIM and Barthel Index. Although all 3 measures showed statistically significant change from admission to discharge (P<.001), only GAS scores strongly correlated with the Clinical Global Impression scale (rho=-.86, P<.001). GAS discharge scores differed significantly between the responder and nonresponder groups (Mann-Whitney, z=-3.78, P<.001). Different measures of effect size gave different results, but GAS was consistently more responsive than either the FIM or Barthel Index.
This preliminary study suggests that GAS is a responsive and useful outcome measure for the rehabilitation of persons with MS, providing added value to standardized outcome measurement.
运用目标达成量表(GAS)来衡量多发性硬化症(MS)患者临床上重要的功能变化,并与用于评估康复进展的标准测量方法相比,评估其反应性。
前瞻性观察队列研究。
澳大利亚维多利亚州的三级住院康复科。
连续选取24名因综合康复计划入院的MS患者。男女比例为10:14,平均年龄±标准差为52.0±8.3岁(范围37 - 62岁)。超过半数(n = 14 [58.3%])患有继发进展型MS。
不适用。
为每位患者与多学科治疗团队共同前瞻性设定的5至10个优先目标计算GAS评分,并与标准结局指标——FIM量表和巴氏指数——在入院时和出院时进行评分比较。根据整体临床综合印象将患者分为反应者和无反应者。
在203个选定目标中,167个目标达到了预期水平。GAS记录了105个FIM和巴氏指数未测量的个体化目标的结局。尽管所有这3项测量指标从入院到出院均显示出统计学上的显著变化(P <.001),但只有GAS评分与临床综合印象量表高度相关(rho = -.86,P <.001)。反应者和无反应者组的GAS出院评分差异显著(曼-惠特尼检验,z = -3.78,P <.001)。不同的效应量测量方法得出了不同的结果,但GAS始终比FIM或巴氏指数更具反应性。
这项初步研究表明,GAS是一种用于MS患者康复的具有反应性且有用的结局测量指标,为标准化结局测量增加了价值。