Iacobellis Gianluca, Barbaro Giuseppe, Gerstein Hertzel C
Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Int J Cardiol. 2008 Aug 29;128(3):424-6. doi: 10.1016/j.ijcard.2007.12.072. Epub 2008 Mar 28.
In this study we sought to evaluate whether increase in echocardiographic epicardial fat thickness, index of cardiac and visceral adiposity, is associated with impaired fasting glucose (IFG). Epicardial fat thickness and fasting plasma glucose (FPG) were measured in 115 consecutive non-diabetic Caucasian subjects [65 men, 50 women, median age of 42 years (range 30-64 years), median body mass index (BMI) of 27 kg/m(2) (range 22-33 kg/m(2)), who underwent routine transthoracic echocardiogram. Study subjects were designated as having normal fasting glucose (NFG) with FPG<100 mg/dl; and IFG with FPG (100 and <126 mg/dl). Epicardial fat thickness was significantly higher in IFG than NFG subjects (8+/-3 vs 6+/-2 mm; 7.1+/-4 vs 5.8+/-3 mm, p<0.001 for both and respectively in men and women. Epicardial fat thickness was significantly correlated with FPG (r=0.60, p<0.001). Our data indicate for the first time that higher epicardial fat thickness is associated with IFG in non-diabetic men and women. Echocardiographic epicardial fat measurement may be an additional tool for diabetes-related cardiac risk stratification.
在本研究中，我们试图评估超声心动图测量的 epicardial 脂肪厚度（即心脏和内脏脂肪指数）的增加是否与空腹血糖受损（IFG）相关。对 115 名连续的非糖尿病白种人受试者[65 名男性，50 名女性，年龄中位数为 42 岁（范围 30 - 64 岁），体重指数（BMI）中位数为 27 kg/m²（范围 22 - 33 kg/m²）]进行了 epicardial 脂肪厚度和空腹血糖（FPG）测量，这些受试者接受了常规经胸超声心动图检查。研究对象被指定为空腹血糖正常（NFG），FPG < 100 mg/dl；以及空腹血糖受损（IFG），FPG为 100 且<126 mg/dl。IFG 受试者的 epicardial 脂肪厚度显著高于 NFG 受试者（男性分别为 8±3 与 6±2 mm；女性分别为 7.1±4 与 5.8±3 mm，两者 p 均<0.001）。epicardial 脂肪厚度与 FPG 显著相关（r = 0.60，p < 0.001）。我们的数据首次表明，在非糖尿病男性和女性中，较高的 epicardial 脂肪厚度与 IFG 相关。超声心动图测量 epicardial 脂肪可能是糖尿病相关心脏风险分层的一种额外工具。
