Moustakas Aristidis, Heldin Carl-Henrik
Ludwig Institute for Cancer Research, Uppsala University, P.O. Box 595, Biomedical Center, SE-751 24 Uppsala, Sweden.
FEBS Lett. 2008 Jun 18;582(14):2051-65. doi: 10.1016/j.febslet.2008.03.027. Epub 2008 Mar 28.
Transforming growth factor beta (TGF-beta) regulates cellular behavior in embryonic and adult tissues. TGF-beta binding to serine/threonine kinase receptors on the plasma membrane activates Smad molecules and additional signaling proteins that coordinately regulate gene expression or cytoplasmic processes such as cytoskeletal dynamics. In turn, the activity and duration of the Smad pathway seems to be regulated by cytoskeletal components, which facilitate the shuttling process that segregates Smad proteins in the cytoplasm and nucleus. We discuss mechanisms and models that aim at explaining the coordination between several components of the signaling network downstream of the TGF-beta signal.
转化生长因子β（TGF-β）调节胚胎组织和成年组织中的细胞行为。TGF-β与质膜上的丝氨酸/苏氨酸激酶受体结合，激活Smad分子和其他信号蛋白，这些蛋白协同调节基因表达或细胞质过程，如细胞骨架动力学。反过来，Smad信号通路的活性和持续时间似乎受细胞骨架成分的调节，细胞骨架成分促进了Smad蛋白在细胞质和细胞核中分离的穿梭过程。我们讨论了旨在解释TGF-β信号下游信号网络中几个成分之间协调作用的机制和模型。
