日本造血干细胞研究的血脉传承。
Bloodlines of haematopoietic stem cell research in Japan.
作者信息
Ema Hideo, Nakauchi Hiromitsu
机构信息
Laboratory of Stem Cell Therapy, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
出版信息
Philos Trans R Soc Lond B Biol Sci. 2008 Jun 27;363(1500):2089-97. doi: 10.1098/rstb.2008.2263.
Haematopoietic stem cells (HSCs) can supply all blood cells throughout the adult life of individuals. Based on this property, HSCs have been used for bone marrow and cord blood transplantation. Among various stem cells, HSCs were recognized earliest and were studied most extensively, providing a model for other stem cells. Knowledge of HSC regulation has rapidly accumulated of late. Contributions of scientists in Japan to progress HSC biology are here briefly overviewed. Focusing on the original work accomplished in Japan in the last two decades, people who have led such activities are introduced and their relationships with one another are sketched.
造血干细胞（HSCs）能够在个体的成年期持续供应所有血细胞。基于这一特性，造血干细胞已被用于骨髓和脐带血移植。在各种干细胞中，造血干细胞是最早被识别且研究最为广泛的，为其他干细胞提供了一个模型。近年来，关于造血干细胞调控的知识迅速积累。本文简要概述了日本科学家对造血干细胞生物学进展所做的贡献。聚焦于日本在过去二十年中完成的原创性工作，介绍了引领这些活动的人物，并勾勒了他们之间的相互关系。
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