Meyer zum Gottesberge A, Schleicher A, Drummer C, Gerzer R
Department of Otorhinolaryngology, Univ. of Düsseldorf, Germany.
Acta Otolaryngol Suppl. 1995;520 Pt 1:170-3. doi: 10.3109/00016489509125219.
It has been suggested that the family of natriuretic peptides (NP) has a protective role in volume overloading. Specific binding sites for atrial natriuretic peptide (ANP) and the kidney analog urodilatin (URO) were identified and quantified with computerized autoradiography and biochemical assay in the cryosection in the cochlear and vestibular (utricle/ampulla) tissue. Immunohistochemistry was used to identify and localize NP-like immunoreactive cells. Different levels of specific receptors between and within the inner ear compartments were detected. The presence of specific receptors for NP, as well as unequal distribution of NP-immunoreactivity between the compartments (in certain parts of the cochlea and the endolymphatic sac), may indicate a local autocrine and/or paracrine action of these peptide systems (presumably as a result of the integration of the different peptide effects), independent of their action via the more conventional systemic route, in addition to differences in response of the inner ear compartments to the load. The present results on specific binding of ANP and URO in the inner ear tissue may suggest physiological homology between the inner ear and the kidney. Moreover, a similar role of NP in these organs is suggested.
有人提出，利钠肽（NP）家族在容量超负荷中具有保护作用。通过计算机放射自显影和生化分析，在耳蜗和前庭（椭圆囊/壶腹）组织的冷冻切片中鉴定并定量了心房利钠肽（ANP）和肾脏类似物尿钠素（URO）的特异性结合位点。免疫组织化学用于鉴定和定位NP样免疫反应细胞。检测到内耳各腔室之间以及内部不同水平的特异性受体。NP特异性受体的存在，以及各腔室之间NP免疫反应性的不均匀分布（在耳蜗和内淋巴囊的某些部位），可能表明这些肽系统存在局部自分泌和/或旁分泌作用（可能是不同肽效应整合的结果），除了内耳各腔室对负荷的反应存在差异外，这一作用独立于它们通过更传统的全身途径发挥的作用。目前关于ANP和URO在内耳组织中特异性结合的结果可能提示内耳与肾脏之间存在生理同源性。此外，还提示NP在这些器官中具有类似作用。
