McKnight J A, Roberts G, Sheridan B, Atkinson A B
Sir George E. Clark Metabolic Unit, Royal Victoria Hospital, Belfast, Northern Ireland, UK.
J Hum Hypertens. 1989 Jun;3(3):157-63.
The relationships between plasma atrial natriuretic factor (ANF), blood pressure (BP) and age have not been clearly defined. We measured plasma ANF levels and BP in 128 normal subjects (65 male; 63 female; mean age 48 years, range 20-87 years) on no medication. In subjects of 75 years or less (n = 120) plasma ANF was 5.7 +/- 0.3 pmol/l (mean +/- SEM). Plasma ANF did not differ between sexes (males 5.6 +/- 0.4 pmol/l, females 5.9 +/- 0.4 pmol/l). There was a positive correlation between plasma ANF and age, correlation coefficient (r) = 0.46, systolic BP (r = 0.44), diastolic BP (r = 0.22) and mean BP (r = 0.37) (all P less than 0.01), but after multiple linear regression analysis plasma ANF only related significantly (P less than 0.01) to age and systolic BP once other factors had been excluded. We also measured plasma ANF after erect and supine posture and during a 21IV normal saline infusion given over 4 hrs (n = 24; age range 21-62 years) after an overnight fast. Mean plasma ANF was 5.9 +/- 1.1 pmol/l erect, 7.4 +/- 1.6 pmol/l supine and rose to 10.1 +/- 1.4 pmol/l after saline (both P less than 0.05 vs basal). Response to saline was assessed as the area under the curve of hourly measurements. Neither this nor peak ANF during saline infusion correlated with age. We conclude that basal plasma ANF is influenced by age and systolic BP but plasma ANF response to acute saline stimulation is not.
血浆心钠素（ANF）、血压（BP）与年龄之间的关系尚未明确界定。我们对128名未服用药物的正常受试者（65名男性；63名女性；平均年龄48岁，范围20 - 87岁）测量了血浆ANF水平和血压。在75岁及以下的受试者（n = 120）中，血浆ANF为5.7±0.3 pmol/l（平均值±标准误）。血浆ANF在性别之间无差异（男性5.6±0.4 pmol/l，女性5.9±0.4 pmol/l）。血浆ANF与年龄、相关系数（r）= 0.46、收缩压（r = 0.44）、舒张压（r = 0.22）和平均血压（r = 0.37）呈正相关（均P＜0.01），但在多线性回归分析后，一旦排除其他因素，血浆ANF仅与年龄和收缩压显著相关（P＜0.01）。我们还在空腹过夜后，对24名受试者（年龄范围21 - 62岁）在直立和仰卧姿势下以及在4小时内静脉输注21IV生理盐水期间测量了血浆ANF。直立时平均血浆ANF为5.9±1.1 pmol/l，仰卧时为7.4±1.6 pmol/l，生理盐水输注后升至10.1±1.4 pmol/l（两者与基础值相比均P＜0.05）。对生理盐水的反应以每小时测量值的曲线下面积评估。这一反应以及生理盐水输注期间的ANF峰值均与年龄无关。我们得出结论，基础血浆ANF受年龄和收缩压影响，但血浆ANF对急性生理盐水刺激的反应不受影响。
