Bernaldez-Rios Roberto, Ortega-Alvarez Manuel C, Perez-Saldivar Maria L, Alatoma-Medina Norma E, Del Campo-Martinez Maria de Los A, Rodriguez-Zepeda Maria Del Carmen, Montero-Ponce Ines, Franco-Ornelas Sergio, Fernandez-Castillo Gabriela, Nuñez-Villegas Nora N, Taboada-Flores Miguel A, Flores-Lujano Janet, Argüelles-Sanchez Muriel E, Juarez-Ocaña Servando, Fajardo-Gutierrez Arturo, Mejia-Arangure Juan Manuel
Hematology, Pediatric Hospital, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
J Pediatr Hematol Oncol. 2008 Mar;30(3):199-203. doi: 10.1097/MPH.0b013e318162bcdc.
The objective of this population-based survey was to assess the peak age of incidence of B-cell precursor acute lymphoblastic leukemia (ALL) in children in Mexico City (MC). All patients were classified according to their immunophenotype, and only B-cell precursor and T-lineage were analyzed. Rates of incidence were calculated x10 children. Of the 364 children from MC who were included in this study, immunophenotyping had been performed for 81.6%. The frequency of B-cell precursor ALL was 76.1%, whereas T lineage ALL showed a frequency of 23.6%. Peak age for ALL was 2 to 3 years of age. B-cell precursor ALL was the major contributor to peak age; T lineage ALL showed a peak among 1 and 3 years of age. We conclude that the age peak for children with ALL in MC is within the ranges reported for developed countries and that B-cell precursor ALL is the main contributor to these peak.
这项基于人群的调查旨在评估墨西哥城（MC）儿童B细胞前体急性淋巴细胞白血病（ALL）的发病高峰年龄。所有患者均根据其免疫表型进行分类，仅分析B细胞前体和T细胞系。发病率按每10万名儿童计算。在纳入本研究的364名来自MC的儿童中，81.6%进行了免疫表型分析。B细胞前体ALL的频率为76.1%，而T细胞系ALL的频率为23.6%。ALL的发病高峰年龄为2至3岁。B细胞前体ALL是发病高峰年龄的主要贡献者；T细胞系ALL在1至3岁之间出现发病高峰。我们得出结论，MC地区ALL患儿的年龄高峰在发达国家报告的范围内，且B细胞前体ALL是这些高峰的主要贡献者。
