Thomaidis Vasilis, Kazakos Kostas, Lyras Dimitris N, Dimitrakopoulos Ioannis, Lazaridis Nikolaos, Karakasis Dimitrios, Botaitis Sotirios, Agrogiannis George
Clinic of Maxillofacial Surgery, University General Hospital of Alexandroupolis, Alexandroupolis, Greece.
Med Sci Monit. 2008 Apr;14(4):BR67-73.
Although several studies have examined use of collagen membranes in guided bone regeneration (GBR), none has examined the use of human fascia temporalis as a bioabsorbable barrier. The majority of studies related to GBR have examined critical size defects. We sought to assess the human fascia temporalis and other well-documented membranes applied for GBR in mandibular osseous defects beyond critical size.
MATERIAL/METHODS: Fifty adult male New Zealand white rabbits were used in this study. Five groups of 10 animals each were used: HFL (human fascia lata membrane), HP (human pericardium), HFT (human fascia temporalis), BP (bovine pericardium), and PTFE (expanded polytetrafluoroethylene). Animals were killed 10 weeks after membrane application. In each animal, 9-mm circular mandibular defects were created bilaterally. On 1 side of the jaw, the defect was covered with 1 of the test membranes; the defect on the other side served as a control. Harvested specimens were examined histologically.
Membranes were significantly superior to the controls in all animals (P<0.001). Paired comparisons showed that groups HFL, HP, BP, and PTFE were significantly superior to HFT (P<0.05). Conversely, comparisons of HFL-HP, HFL-BP, HFL-PTFE, HP-BP, HP-PTFE, and BP-PTFE, showed no significant differences (P>0.05).
According to our results, the fascia temporalis is not recommended for GBR techniques. The fascia lata, human pericardium, bovine pericardium, and e-PTFE advance bone regeneration and can be successfully used as GBR membranes for osseous defects beyond the critical size.
尽管多项研究已探讨了胶原膜在引导骨再生（GBR）中的应用，但尚无研究考察人颞肌筋膜作为生物可吸收屏障的用途。大多数与GBR相关的研究都考察了临界尺寸骨缺损。我们试图评估人颞肌筋膜以及其他有充分文献记载的膜在下颌骨临界尺寸以上骨缺损的GBR中的应用情况。
材料/方法：本研究使用了50只成年雄性新西兰白兔。将其分为五组，每组10只动物：HFL（人阔筋膜）、HP（人心包膜）、HFT（人颞肌筋膜）、BP（牛心包膜）和PTFE（膨体聚四氟乙烯）。在植入膜10周后处死动物。在每只动物双侧制造9毫米的圆形下颌骨缺损。在一侧颌骨，缺损用一种测试膜覆盖；另一侧的缺损作为对照。对采集的标本进行组织学检查。
在所有动物中，膜均显著优于对照组（P<0.001）。配对比较显示，HFL、HP、BP和PTFE组显著优于HFT组（P<0.05）。相反，HFL与HP、HFL与BP、HFL与PTFE、HP与BP、HP与PTFE以及BP与PTFE之间的比较均无显著差异（P>0.05）。
根据我们的结果，不建议将颞肌筋膜用于GBR技术。阔筋膜、人心包膜、牛心包膜和膨体聚四氟乙烯可促进骨再生，并可成功用作临界尺寸以上骨缺损的GBR膜。
