Democritus University of Thrace, Department of Orthopaedics and Traumatology, Dragana, 68100 Alexandroupolis, Greece.
J Craniomaxillofac Surg. 2011 Jan;39(1):49-53. doi: 10.1016/j.jcms.2010.03.005. Epub 2010 Apr 24.
The aim of this study was to assess the hypothesis that application of platelet-rich plasma (PRP) gel in mandibular defects in rabbits, alone or in combination with guided bone regeneration (GBR) techniques, could enhance the bone healing process.
Thirty New Zealand white rabbits were used. Three groups of 10 animals each were assigned, and the animals were sacrificed after 12 weeks. During the operation, a rotating trephine bur was used to create circular defects 10-mm in diameter in the region anterior to the jaw angles. In group human fascia lata (HFL), a human fascia lata membrane was used. In group PRP, PRP gel was used to fill the defect, and in group HFL+PRP, PRP was used to fill the defect which after that was covered with a human fascia lata membrane.
In general, none of the control sides and the PRP treated sides had full development of bone or filling of the defect through bone bridging. Conversely, the sides on which the fascia lata membrane or the combination of membrane and PRP had been applied were characterized mostly by development of newly formed bone that bridged the gap.
Our results suggest that the application of PRP gel alone or in combination with GBR does not enhance bone healing process.
本研究旨在评估以下假设，即在兔下颌骨缺损中应用富血小板血浆（PRP）凝胶，单独或结合引导骨再生（GBR）技术，能否促进骨愈合过程。
使用 30 只新西兰白兔。将动物分为 3 组，每组 10 只，术后 12 周处死动物。手术中，使用旋转环钻在颌角前区创建直径为 10mm 的圆形缺损。在筋膜组（HFL）中，使用人阔筋膜。在 PRP 组中，用 PRP 凝胶填充缺损，在 HFL+PRP 组中，先用 PRP 填充缺损，然后用阔筋膜覆盖。
一般来说，对照组和 PRP 治疗组的骨缺损均未完全通过骨桥形成来修复。相反，应用阔筋膜或膜与 PRP 联合应用的侧方则主要表现为新形成的骨桥接了间隙。
我们的结果表明，单独应用 PRP 凝胶或结合 GBR 并不能促进骨愈合过程。
