针对个别帕金森病小鼠的治疗性克隆
Therapeutic cloning in individual parkinsonian mice.
作者信息
Tabar Viviane, Tomishima Mark, Panagiotakos Georgia, Wakayama Sayaka, Menon Jayanthi, Chan Bill, Mizutani Eiji, Al-Shamy George, Ohta Hiroshi, Wakayama Teruhiko, Studer Lorenz
机构信息
Department of Neurosurgery, Sloan-Kettering Institute, 1275 York Ave, New York, New York 10065, USA.
出版信息
Nat Med. 2008 Apr;14(4):379-81. doi: 10.1038/nm1732. Epub 2008 Mar 23.
Abstract
Cell transplantation with embryonic stem (ES) cell progeny requires immunological compatibility with host tissue. 'Therapeutic cloning' is a strategy to overcome this limitation by generating nuclear transfer (nt)ES cells that are genetically matched to an individual. Here we establish the feasibility of treating individual mice via therapeutic cloning. Derivation of 187 ntES cell lines from 24 parkinsonian mice, dopaminergic differentiation, and transplantation into individually matched host mice showed therapeutic efficacy and lack of immunological response.
摘要
用胚胎干细胞（ES细胞）后代进行细胞移植需要与宿主组织具有免疫相容性。“治疗性克隆”是一种通过产生与个体基因匹配的核移植（nt）ES细胞来克服这一限制的策略。在这里，我们证实了通过治疗性克隆治疗个体小鼠的可行性。从24只帕金森病小鼠中获得187个ntES细胞系，进行多巴胺能分化，并移植到个体匹配的宿主小鼠中，显示出治疗效果且无免疫反应。
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