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Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes.
Nat Struct Mol Biol. 2008 Apr;15(4):422-3. doi: 10.1038/nsmb.1404. Epub 2008 Mar 23.
2
Ligand binding regions in the receptor for urokinase-type plasminogen activator.
J Biol Chem. 2001 Aug 3;276(31):28946-53. doi: 10.1074/jbc.m011347200.
4
Crystal structure of the urokinase receptor in a ligand-free form.
J Mol Biol. 2012 Mar 9;416(5):629-41. doi: 10.1016/j.jmb.2011.12.058. Epub 2012 Jan 21.
5
Stabilizing a flexible interdomain hinge region harboring the SMB binding site drives uPAR into its closed conformation.
J Mol Biol. 2015 Mar 27;427(6 Pt B):1389-1403. doi: 10.1016/j.jmb.2015.01.022. Epub 2015 Feb 7.
7
Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide.
EMBO J. 2005 May 4;24(9):1655-63. doi: 10.1038/sj.emboj.7600635. Epub 2005 Apr 7.
9
Sequences within domain II of the urokinase receptor critical for differential ligand recognition.
J Biol Chem. 2003 Aug 8;278(32):29925-32. doi: 10.1074/jbc.M300751200. Epub 2003 May 20.
10
Structural basis of interaction between urokinase-type plasminogen activator and its receptor.
J Mol Biol. 2006 Oct 20;363(2):482-95. doi: 10.1016/j.jmb.2006.08.063. Epub 2006 Aug 26.

引用本文的文献

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The Light Chain Allosterically Enhances the Protease Activity of Murine Urokinase-Type Plasminogen Activator.
Biochemistry. 2024 Jun 4;63(11):1434-1444. doi: 10.1021/acs.biochem.4c00071. Epub 2024 May 23.
3
Deficiency of Urokinase-Type Plasminogen Activator Receptor Is Associated with the Development of Perivascular Fibrosis in Mouse Heart.
Bull Exp Biol Med. 2022 May;173(1):5-9. doi: 10.1007/s10517-022-05480-9. Epub 2022 May 27.
4
Modulation of Cellular Function by the Urokinase Receptor Signalling: A Mechanistic View.
Front Cell Dev Biol. 2022 Apr 8;10:818616. doi: 10.3389/fcell.2022.818616. eCollection 2022.
5
Vitronectin, a Novel Urinary Proteomic Biomarker, Promotes Cell Pyroptosis in Juvenile Systemic Lupus Erythematosus.
Mediators Inflamm. 2022 Apr 13;2022:8447675. doi: 10.1155/2022/8447675. eCollection 2022.
6
Crystal structure and cellular functions of uPAR dimer.
Nat Commun. 2022 Mar 29;13(1):1665. doi: 10.1038/s41467-022-29344-y.
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uPAR: An Essential Factor for Tumor Development.
J Cancer. 2021 Oct 17;12(23):7026-7040. doi: 10.7150/jca.62281. eCollection 2021.

本文引用的文献

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uPAR-induced cell adhesion and migration: vitronectin provides the key.
J Cell Biol. 2007 Jun 4;177(5):927-39. doi: 10.1083/jcb.200612058.
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Does the urokinase receptor exist in a latent form?
Cell Mol Life Sci. 2007 May;64(9):1033-7. doi: 10.1007/s00018-007-6498-z.
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Structure of human urokinase plasminogen activator in complex with its receptor.
Science. 2006 Feb 3;311(5761):656-9. doi: 10.1126/science.1121143.
5
Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide.
EMBO J. 2005 May 4;24(9):1655-63. doi: 10.1038/sj.emboj.7600635. Epub 2005 Apr 7.
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How vitronectin binds PAI-1 to modulate fibrinolysis and cell migration.
Nat Struct Biol. 2003 Jul;10(7):541-4. doi: 10.1038/nsb943.
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uPAR: a versatile signalling orchestrator.
Nat Rev Mol Cell Biol. 2002 Dec;3(12):932-43. doi: 10.1038/nrm977.
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Urokinase regulates vitronectin binding by controlling urokinase receptor oligomerization.
J Biol Chem. 2002 Aug 2;277(31):27982-90. doi: 10.1074/jbc.M111736200. Epub 2002 May 28.

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