Huai Qing, Zhou Aiwu, Lin Lin, Mazar Andrew P, Parry Graham C, Callahan Jennifer, Shaw David E, Furie Bruce, Furie Barbara C, Huang Mingdong
Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA.
Nat Struct Mol Biol. 2008 Apr;15(4):422-3. doi: 10.1038/nsmb.1404. Epub 2008 Mar 23.
The urokinase receptor (uPAR) can recognize several ligands. The structural basis for this multiple ligand recognition by uPAR is unknown. This study reports the crystal structures of uPAR in complex with both urokinase (uPA) and vitronectin and reveal that uPA occupies the central cavity of the receptor, whereas vitronectin binds at the outer side of the receptor. These results provide a structural understanding of one receptor binding to two ligands.
尿激酶受体(uPAR)能够识别多种配体。uPAR这种多配体识别的结构基础尚不清楚。本研究报告了uPAR与尿激酶(uPA)和玻连蛋白形成复合物的晶体结构,结果显示uPA占据受体的中央腔,而玻连蛋白则结合在受体外侧。这些结果为一个受体结合两种配体提供了结构上的理解。