自身免疫性孕酮性皮炎。伴有多形红斑和荨麻疹组织学重叠的病例报告。
Autoimmune progesterone dermatitis. Case report with histologic overlap of erythema multiforme and urticaria.
作者信息
Walling Hobart W, Scupham Richard K
机构信息
Private Practice of Dermatology and Iowa Pathology Associates, Des Moines, Iowa, USA.
出版信息
Int J Dermatol. 2008 Apr;47(4):380-2. doi: 10.1111/j.1365-4632.2008.03395.x.
BACKGROUND
Autoimmune progesterone dermatitis is a rare eruption that recurs monthly as progesterone levels peak during the menstrual cycle. Clinical and histologic features are variable, and the eruption is thought to represent a hypersensitivity response to endogenous progesterone.
METHODS
We present the case of a 38-year-old woman with a pruritic intermittent facial eruption of 18 months' duration that recurred predictably in the days surrounding menses.
RESULTS
The histology showed interface dermatitis with features of both erythema multiforme and urticaria. Intradermal injection of medroxyprogesterone acetate was positive. Her symptoms responded to antihistamine therapy.
CONCLUSION
This unusual case is particularly distinctive both in terms of the histologic findings and the response to therapy.
背景
自身免疫性孕酮性皮炎是一种罕见的皮疹，随着月经周期中孕酮水平在每月达到峰值时复发。临床和组织学特征各不相同，这种皮疹被认为是对内源性孕酮的超敏反应。
方法
我们报告了一名38岁女性的病例，她有持续18个月的间歇性面部瘙痒性皮疹，在月经前后几天可预测地复发。
结果
组织学显示界面性皮炎，具有多形红斑和荨麻疹的特征。皮内注射醋酸甲羟孕酮呈阳性。她的症状对抗组胺治疗有反应。
结论
这个不寻常的病例在组织学发现和治疗反应方面都特别独特。
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