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正电子发射断层显像-计算机断层扫描(PET-CT)在晚期头颈癌患者管理中的作用

The role of PET-CT in the management of patients with advanced cancer of the head and neck.

作者信息

Corry June, Rischin Danny, Hicks Rodney J, Peters Lester J

机构信息

Division of Radiation Oncology, Peter MacCallum Cancer Centre, Locked Bag No 1, A'Beckett Street, Melbourne 8006, Australia.

出版信息

Curr Oncol Rep. 2008 Mar;10(2):149-55. doi: 10.1007/s11912-008-0023-x.

DOI:10.1007/s11912-008-0023-x
PMID:18377828
Abstract

The development of functional imaging using positron emission tomography (PET) has been a major advancement in clinical oncology. In addition, the integration of functional imaging with CT anatomical imaging (PET-CT) has dramatically increased the clinical applicability of PET. This review discusses the current role of PET-CT in head and neck cancer, focusing on its role in staging, detection of unknown primaries, radiotherapy planning, assessment of treatment response, and biological characterization of disease. We also demonstrate why PET-CT should be an integral part of modern management of head and neck cancer.

摘要

使用正电子发射断层扫描(PET)的功能成像技术发展是临床肿瘤学的一项重大进展。此外,功能成像与CT解剖成像(PET-CT)的整合显著提高了PET的临床适用性。本综述讨论了PET-CT在头颈癌中的当前作用,重点关注其在分期、未知原发灶检测、放射治疗计划、治疗反应评估以及疾病生物学特征方面的作用。我们还阐述了为什么PET-CT应该成为现代头颈癌管理不可或缺的一部分。

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本文引用的文献

1
Evaluation of head and neck cancer with (18)F-FDG PET: a comparison with conventional methods.(18)F-FDG PET对头颈部癌的评估:与传统方法的比较。
Eur J Nucl Med. 2001 Jul;28(7):816-21. doi: 10.1007/s002590100554.
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Hypoxia in head and neck cancer: studies with hypoxic positron emission tomography imaging and hypoxic cytotoxins.头颈癌中的缺氧:正电子发射断层扫描成像和缺氧细胞毒素相关研究
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正电子发射断层扫描和单光子发射计算机断层扫描分子成像引导放射治疗的前景与陷阱。
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MMP9 but Not EGFR, MET, ERCC1, P16, and P-53 Is Associated with Response to Concomitant Radiotherapy, Cetuximab, and Weekly Cisplatin in Patients with Locally Advanced Head and Neck Cancer.MMP9 而非 EGFR、MET、ERCC1、P16 和 P-53 与局部晚期头颈部癌症患者同步放化疗联合西妥昔单抗和每周顺铂的反应相关。
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[124I]IAZA与[18F]FMISO和[18F]FAZA相比用于肿瘤缺氧成像——首例小动物PET结果
J Pharm Pharm Sci. 2007;10(2):203-11.
4
Clinical impact of, and prognostic stratification by, F-18 FDG PET/CT in head and neck mucosal squamous cell carcinoma.F-18 FDG PET/CT对头颈部黏膜鳞状细胞癌的临床影响及预后分层
Head Neck. 2007 Nov;29(11):986-95. doi: 10.1002/hed.20629.
5
18F-FLT PET does not discriminate between reactive and metastatic lymph nodes in primary head and neck cancer patients.18F-FLT正电子发射断层扫描(PET)无法区分原发性头颈癌患者的反应性淋巴结和转移性淋巴结。
J Nucl Med. 2007 May;48(5):726-35. doi: 10.2967/jnumed.106.037473.
6
Tumour hypoxia imaging with [18F]FAZA PET in head and neck cancer patients: a pilot study.头颈部癌患者中使用[18F]FAZA PET进行肿瘤缺氧成像:一项初步研究。
Eur J Nucl Med Mol Imaging. 2007 Oct;34(10):1566-75. doi: 10.1007/s00259-007-0424-3. Epub 2007 Apr 20.
7
Impact of FDG-PET/CT imaging on nodal staging for head-and-neck squamous cell carcinoma.氟代脱氧葡萄糖正电子发射断层扫描/计算机断层扫描(FDG-PET/CT)成像对头颈部鳞状细胞癌淋巴结分期的影响
Int J Radiat Oncol Biol Phys. 2007 Jun 1;68(2):377-82. doi: 10.1016/j.ijrobp.2006.12.032. Epub 2007 Feb 22.
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PET tracer development--a tale of mice and men.正电子发射断层显像(PET)示踪剂的研发——人与小鼠的故事
Cancer Imaging. 2006 Oct 31;6(Spec No A):S102-6. doi: 10.1102/1470-7330.2006.9098.
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Role of neck dissection following concurrent chemoradiation for advanced head and neck carcinoma.同步放化疗后颈部清扫术在晚期头颈癌治疗中的作用。
Head Neck. 2006 Dec;28(12):1099-105. doi: 10.1002/hed.20479.
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Posttreatment assessment of response using FDG-PET/CT for patients treated with definitive radiation therapy for head and neck cancers.对头颈部癌接受根治性放射治疗的患者,使用氟代脱氧葡萄糖正电子发射断层显像/X线计算机体层成像(FDG-PET/CT)进行治疗后反应评估。
Int J Radiat Oncol Biol Phys. 2006 Aug 1;65(5):1315-22. doi: 10.1016/j.ijrobp.2006.03.015. Epub 2006 Jun 5.