Deantonio Letizia, Beldì Debora, Gambaro Giuseppina, Loi Gianfranco, Brambilla Marco, Inglese Eugenio, Krengli Marco
Radiotherapy, University of Piemonte Orientale Amedeo Avogadro, Novara, Italy.
Radiat Oncol. 2008 Sep 18;3:29. doi: 10.1186/1748-717X-3-29.
Positron emission tomography (PET) has a potential improvement for staging and radiation treatment planning of various tumor sites. We analyzed the use of 18F-fluorodeoxyglucose (FDG)-PET/computed tomography (CT) images for staging and target volume delineation of patients with head and neck carcinoma candidates for radiotherapy.
Twenty-two patients candidates for primary radiotherapy, who did not receive any curative surgery, underwent both CT and PET/CT simulation. Gross Tumor Volume (GTV) was contoured on CT (CT-GTV), PET (PET-GTV), and PET/CT images (PET/CT-GTV). The resulting volumes were analyzed and compared.
Based on PET/CT, changes in TNM categories and clinical stage occurred in 5/22 cases (22%). The difference between CT-GTV and PET-GTV was not statistically significant (p = 0.2) whereas the difference between the composite volume (PET/CT-GTV) and CT-GTV was statistically significant (p < 0.0001).
PET/CT fusion images could have a potential impact on both tumor staging and treatment planning.
正电子发射断层扫描（PET）在各种肿瘤部位的分期和放射治疗计划方面有潜在的改进作用。我们分析了18F-氟脱氧葡萄糖（FDG）-PET/计算机断层扫描（CT）图像在头颈部癌放疗候选患者分期及靶区勾画中的应用。
22例未接受过任何根治性手术的原发性放疗候选患者接受了CT和PET/CT模拟。在CT（CT-GTV）、PET（PET-GTV）和PET/CT图像（PET/CT-GTV）上勾画大体肿瘤体积（GTV）。对所得体积进行分析和比较。
基于PET/CT，22例中有5例（22%）的TNM分类和临床分期发生了变化。CT-GTV与PET-GTV之间的差异无统计学意义（p = 0.2），而复合体积（PET/CT-GTV）与CT-GTV之间的差异有统计学意义（p < 0.0001）。
PET/CT融合图像可能对肿瘤分期和治疗计划有潜在影响。
