Lipari Christopher W, Garcia Jairo E, Zhao Yulian, Thrift Kimberly, Vaidya Dhananjay, Rodriguez Annabelle
Department of Gynecology and Obstetrics, Division of Reproductive Endocrinology and Infertility, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA.
Fertil Steril. 2009 Apr;91(4 Suppl):1316-8. doi: 10.1016/j.fertnstert.2008.01.108. Epub 2008 Apr 18.
Eleven patients underwent controlled ovarian hyperstimulation yielding 72 embryos for evaluation. Mean nitric oxide metabolite levels in the insemination media were 2.6 times higher in embryos that progressed to blastocysts by culture day 5 than in those that did not. A comparison of the receiver operating characteristic curves between morphological predictors and nitric oxide metabolite levels revealed a trend toward a stronger association of insemination media nitric oxide metabolite with blastocyst formation.
11名患者接受了控制性卵巢过度刺激，获得72个胚胎用于评估。在培养第5天发育为囊胚的胚胎的受精培养基中，一氧化氮代谢物的平均水平比未发育为囊胚的胚胎高2.6倍。形态学预测指标与一氧化氮代谢物水平之间的受试者工作特征曲线比较显示，受精培养基中的一氧化氮代谢物与囊胚形成之间的关联有更强的趋势。
