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用于肌腱组织再生的仿生支架

Biomimetic Scaffolds for Tendon Tissue Regeneration.

作者信息

Huang Lvxing, Chen Le, Chen Hengyi, Wang Manju, Jin Letian, Zhou Shenghai, Gao Lexin, Li Ruwei, Li Quan, Wang Hanchang, Zhang Can, Wang Junjuan

机构信息

School of Savaid Stomatology, Hangzhou Medical College, Hangzhou 310000, China.

School of Basic Medical Sciences and Forensic Medicine, Hangzhou Medical College, Hangzhou 310000, China.

出版信息

Biomimetics (Basel). 2023 Jun 9;8(2):246. doi: 10.3390/biomimetics8020246.

DOI:10.3390/biomimetics8020246
PMID:37366841
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10296678/
Abstract

Tendon tissue connects muscle to bone and plays crucial roles in stress transfer. Tendon injury remains a significant clinical challenge due to its complicated biological structure and poor self-healing capacity. The treatments for tendon injury have advanced significantly with the development of technology, including the use of sophisticated biomaterials, bioactive growth factors, and numerous stem cells. Among these, biomaterials that the mimic extracellular matrix (ECM) of tendon tissue would provide a resembling microenvironment to improve efficacy in tendon repair and regeneration. In this review, we will begin with a description of the constituents and structural features of tendon tissue, followed by a focus on the available biomimetic scaffolds of natural or synthetic origin for tendon tissue engineering. Finally, we will discuss novel strategies and present challenges in tendon regeneration and repair.

摘要

肌腱组织将肌肉与骨骼相连，在应力传递中发挥着关键作用。由于其复杂的生物学结构和较差的自我修复能力，肌腱损伤仍然是一个重大的临床挑战。随着技术的发展，肌腱损伤的治疗方法有了显著进步，包括使用精密的生物材料、生物活性生长因子和大量干细胞。其中，模拟肌腱组织细胞外基质（ECM）的生物材料将提供类似的微环境，以提高肌腱修复和再生的效果。在这篇综述中，我们将首先描述肌腱组织的组成成分和结构特征，接着重点介绍用于肌腱组织工程的天然或合成来源的仿生支架。最后，我们将讨论肌腱再生和修复的新策略以及面临的挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eac/10296678/757cd90e1d94/biomimetics-08-00246-g017.jpg
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