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1
Ecological implications of glucosyltransferase phase variation in Streptococcus gordonii.戈登氏链球菌中葡糖基转移酶相变的生态学意义
Appl Environ Microbiol. 1991 Dec;57(12):3648-51. doi: 10.1128/aem.57.12.3648-3651.1991.
2
Sucrose-promoted accumulation of growing glucosyltransferase variants of Streptococcus gordonii on hydroxyapatite surfaces.蔗糖促进戈登氏链球菌生长的葡糖基转移酶变体在羟基磷灰石表面的积累。
Infect Immun. 1991 Oct;59(10):3523-30. doi: 10.1128/iai.59.10.3523-3530.1991.
3
Deletions in the carboxyl-terminal region of Streptococcus gordonii glucosyltransferase affect cell-associated enzyme activity and sucrose-associated accumulation of growing cells.戈登氏链球菌葡糖基转移酶羧基末端区域的缺失影响生长细胞的细胞相关酶活性和蔗糖相关积累。
Appl Environ Microbiol. 1997 May;63(5):1667-73. doi: 10.1128/aem.63.5.1667-1673.1997.
4
Adhesion of glucosyltransferase phase variants to Streptococcus gordonii bacterium-glucan substrata may involve lipoteichoic acid.葡糖基转移酶相变体与戈登链球菌细菌葡聚糖基质的黏附可能涉及脂磷壁酸。
Infect Immun. 1992 Oct;60(10):4301-8. doi: 10.1128/iai.60.10.4301-4308.1992.
5
Glucosyltransferase phase variation in Streptococcus gordonii modifies adhesion to saliva-coated hydroxyapatite surfaces in a sucrose-independent manner.戈登链球菌中的葡糖基转移酶相变以不依赖蔗糖的方式改变对唾液包被的羟基磷灰石表面的黏附。
Oral Microbiol Immunol. 1992 Apr;7(2):118-20. doi: 10.1111/j.1399-302x.1992.tb00521.x.
6
Streptococcus gordonii's sequenced strain CH1 glucosyltransferase determines persistent but not initial colonization of teeth of rats.戈登氏链球菌的测序菌株CH1葡糖基转移酶决定大鼠牙齿的持续性而非初始定植。
Arch Oral Biol. 2008 Feb;53(2):133-40. doi: 10.1016/j.archoralbio.2007.08.011. Epub 2007 Oct 24.
7
Molecular analysis of representative Streptococcus gordonii Spp phase variants reveals no differences in the glucosyltransferase structural gene, gtfG.对代表性戈登链球菌属相变变体的分子分析表明，葡糖基转移酶结构基因gtfG没有差异。
Oral Microbiol Immunol. 1997 Apr;12(2):82-90. doi: 10.1111/j.1399-302x.1997.tb00622.x.
8
Glucan-binding domain of a glucosyltransferase from Streptococcus sobrinus: isolation of a 55-kilodalton peptide from a trypsin digest of glucosyltransferase prebound to insoluble glucan.来自远缘链球菌的葡糖基转移酶的葡聚糖结合结构域：从预先结合到不溶性葡聚糖上的葡糖基转移酶的胰蛋白酶消化产物中分离出一个55千道尔顿的肽段。
Infect Immun. 1989 Jul;57(7):2210-3. doi: 10.1128/iai.57.7.2210-2213.1989.
9
Changes in the carboxyl-terminal repeat region affect extracellular activity and glucan products of Streptococcus gordonii glucosyltransferase.羧基末端重复区域的变化会影响戈登氏链球菌葡糖基转移酶的细胞外活性和葡聚糖产物。
Infect Immun. 1996 Dec;64(12):5117-28. doi: 10.1128/iai.64.12.5117-5128.1996.
10
Structure and enzymatic properties of genetically truncated forms of the water-insoluble glucan-synthesizing glucosyltransferase from Streptococcus sobrinus.来自远缘链球菌的水不溶性葡聚糖合成葡糖基转移酶基因截短形式的结构与酶学性质
J Biochem. 1999 Aug;126(2):287-95. doi: 10.1093/oxfordjournals.jbchem.a022447.

引用本文的文献

1
Growth, development, and gene expression in a persistent Streptococcus gordonii biofilm.戈登氏链球菌持续生物膜中的生长、发育及基因表达
Infect Immun. 2003 Aug;71(8):4759-66. doi: 10.1128/IAI.71.8.4759-4766.2003.
2
Genetic analysis of the rgg-gtfG junctional region and its role in Streptococcus gordonii glucosyltransferase activity.戈登氏链球菌葡糖基转移酶活性中rgg - gtfG连接区域的遗传分析及其作用
Infect Immun. 2002 Apr;70(4):1703-14. doi: 10.1128/IAI.70.4.1703-1714.2002.
3
Deletions in the carboxyl-terminal region of Streptococcus gordonii glucosyltransferase affect cell-associated enzyme activity and sucrose-associated accumulation of growing cells.戈登氏链球菌葡糖基转移酶羧基末端区域的缺失影响生长细胞的细胞相关酶活性和蔗糖相关积累。
Appl Environ Microbiol. 1997 May;63(5):1667-73. doi: 10.1128/aem.63.5.1667-1673.1997.
4
Changes in the carboxyl-terminal repeat region affect extracellular activity and glucan products of Streptococcus gordonii glucosyltransferase.羧基末端重复区域的变化会影响戈登氏链球菌葡糖基转移酶的细胞外活性和葡聚糖产物。
Infect Immun. 1996 Dec;64(12):5117-28. doi: 10.1128/iai.64.12.5117-5128.1996.
5
Phase variation of slime production in Staphylococcus aureus: implications in colonization and virulence.金黄色葡萄球菌中黏液产生的相变：对定植和毒力的影响。
Infect Immun. 1993 Nov;61(11):4857-62. doi: 10.1128/iai.61.11.4857-4862.1993.
6
Oral streptococci with genetic determinants similar to the glucosyltransferase regulatory gene, rgg.具有与葡糖基转移酶调控基因rgg相似的遗传决定因素的口腔链球菌。
Infect Immun. 1995 Nov;63(11):4524-7. doi: 10.1128/iai.63.11.4524-4527.1995.
7
Adhesion of glucosyltransferase phase variants to Streptococcus gordonii bacterium-glucan substrata may involve lipoteichoic acid.葡糖基转移酶相变体与戈登链球菌细菌葡聚糖基质的黏附可能涉及脂磷壁酸。
Infect Immun. 1992 Oct;60(10):4301-8. doi: 10.1128/iai.60.10.4301-4308.1992.

本文引用的文献

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Synthesis of a Polysaccharide from Sucrose by Streptococcus S.B.E.链球菌S.B.E.利用蔗糖合成多糖
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2
Synthesis of insoluble dextran and its significance in the formation of gelatinous deposits by plaque-forming streptococci.不溶性葡聚糖的合成及其在形成菌斑的链球菌产生凝胶状沉积物过程中的意义。
Arch Oral Biol. 1968 Oct;13(10):1249-62. doi: 10.1016/0003-9969(68)90081-2.
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The presence of dextran-forming bacteria, resembling Streptococcus bovis and Streptococcus anguis, in human dental plaque.在人类牙菌斑中存在类似牛链球菌和咽峡炎链球菌的产葡聚糖细菌。
Arch Oral Biol. 1967 Oct;12(10):1199-202. doi: 10.1016/0003-9969(67)90069-6.
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Role of Streptococcus mutans in human dental decay.变形链球菌在人类龋齿中的作用。
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5
Dextransucrase: a glucosyltransferase from Streptococcus sanguis.葡聚糖蔗糖酶：一种来自血链球菌的葡糖基转移酶。
Methods Enzymol. 1987;138:649-61. doi: 10.1016/0076-6879(87)38059-0.
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Regulation of lateral flagella gene transcription in Vibrio parahaemolyticus.副溶血性弧菌中侧向鞭毛基因转录的调控
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Genetic mechanisms of bacterial antigenic variation.细菌抗原变异的遗传机制。
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8
Spontaneous switching of the sucrose-promoted colony phenotype in Streptococcus sanguis.血链球菌中蔗糖促进菌落表型的自发转换
Infect Immun. 1989 Dec;57(12):3945-8. doi: 10.1128/iai.57.12.3945-3948.1989.
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Regulation of expression of Streptococcus mutans genes important to virulence.变形链球菌毒力相关基因表达的调控。
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Comparison of the initial streptococcal microflora on dental enamel in caries-active and in caries-inactive individuals.龋病活跃个体与无龋个体牙釉质初始链球菌菌群的比较。
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戈登氏链球菌中葡糖基转移酶相变的生态学意义

Ecological implications of glucosyltransferase phase variation in Streptococcus gordonii.

作者信息

Vickerman M M, Clewell D B, Jones G W

机构信息

Department of Cariology and General Dentistry, School of Dentistry, Unviersity of Michigan, Ann Arbor 48109-0620.

出版信息

Appl Environ Microbiol. 1991 Dec;57(12):3648-51. doi: 10.1128/aem.57.12.3648-3651.1991.

DOI:10.1128/aem.57.12.3648-3651.1991
PMID:1838470
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC184028/
Abstract

When sucrose is provided as a substrate for glucosyltransferase (GTF), Spp+ cells of the oral bacteria Streptococcus gordonii grow embedded in an insoluble glucan mass associated with surfaces. Spp- phase variants with lower GTF activity, which either arise from or are grown with Spp+ cells, segregate preferentially as unattached cells in the culture supernatants. Conversely, Spp+ revertants preferentially accumulate on surfaces. GTF phase variation, therefore, may facilitate the dispersion of S. gordonii cells throughout the oral cavity.

摘要

当蔗糖作为葡糖基转移酶（GTF）的底物时，口腔细菌戈登链球菌的Spp +细胞生长在与表面相关的不溶性葡聚糖团块中。具有较低GTF活性的Spp-相变体，其要么由Spp +细胞产生，要么与Spp +细胞一起生长，它们优先作为未附着的细胞分离到培养上清液中。相反，Spp +回复体优先在表面聚集。因此，GTF相变异可能有助于戈登链球菌细胞在整个口腔中的扩散。