真核生物依赖DNA的RNA聚合酶的早期进化
Early evolution of eukaryotic DNA-dependent RNA polymerases.
作者信息
Kwapisz Marta, Beckouët Frédéric, Thuriaux Pierre
机构信息
CEA, iBiTec-S, Service de Biologie Intégrative et Génétique Moléculaire, Gif-sur-Yvette F-91191, France.
出版信息
Trends Genet. 2008 May;24(5):211-5. doi: 10.1016/j.tig.2008.02.002. Epub 2008 Apr 1.
Eukaryotic DNA-dependent RNA polymerases (Pol I-III) share a conserved core of 12 subunits, which is closely related to archaeal RNA polymerases. Rpb8, a subunit found in Pol I, II and III, was thought to be restricted to eukaryotes. We show here that Rpb8 closely resembles an archaeal protein called G, found only in Crenarchaea, which identifies a last missing link between the core structure of archaeal and eukaryotic RNA polymerases.
真核生物依赖DNA的RNA聚合酶（Pol I - III）共有一个由12个亚基组成的保守核心，该核心与古细菌RNA聚合酶密切相关。Rpb8是在Pol I、II和III中发现的一个亚基，曾被认为仅存在于真核生物中。我们在此表明，Rpb8与一种仅在泉古菌中发现的名为G的古细菌蛋白极为相似，这揭示了古细菌和真核生物RNA聚合酶核心结构之间最后一个缺失的环节。
Zotero 插件