关于核的起源：一个假说。
On the origin of the nucleus: a hypothesis.
机构信息
MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, United Kingdom.
Department of Marine Microbiology and Biogeochemistry, NIOZ, Royal Netherlands Institute for Sea Research, Den Burg, the Netherlands.
出版信息
Microbiol Mol Biol Rev. 2023 Dec 20;87(4):e0018621. doi: 10.1128/mmbr.00186-21. Epub 2023 Nov 29.
SUMMARYIn this hypothesis article, we explore the origin of the eukaryotic nucleus. In doing so, we first look afresh at the nature of this defining feature of the eukaryotic cell and its core functions-emphasizing the utility of seeing the eukaryotic nucleoplasm and cytoplasm as distinct regions of a common compartment. We then discuss recent progress in understanding the evolution of the eukaryotic cell from archaeal and bacterial ancestors, focusing on phylogenetic and experimental data which have revealed that many eukaryotic machines with nuclear activities have archaeal counterparts. In addition, we review the literature describing the cell biology of representatives of the TACK and Asgardarchaeaota - the closest known living archaeal relatives of eukaryotes. Finally, bringing these strands together, we propose a model for the archaeal origin of the nucleus that explains much of the current data, including predictions that can be used to put the model to the test.
摘要 在这篇假说文章中，我们探讨了真核细胞核的起源。在这样做的过程中，我们首先重新审视了真核细胞这一定义特征及其核心功能的本质——强调将真核核质和细胞质视为共同隔室的不同区域的实用性。然后，我们讨论了从古菌和细菌祖先理解真核细胞进化的最新进展，重点关注揭示具有核活性的许多真核机器具有古菌对应物的系统发育和实验数据。此外，我们还回顾了描述 TACK 和 Asgardarchaeaota 代表的细胞生物学的文献——它们是已知最接近真核生物的活体古菌。最后，将这些线索联系起来，我们提出了一个解释当前大部分数据的核的古菌起源模型，包括可以用来检验该模型的预测。
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