Pinna Antonio, Solinas Giuliana, Masia Carlo, Zinellu Angelo, Carru Ciriaco, Carta Arturo
Institute of Ophthalmology, University of Sassari, Sassari, Italy.
Invest Ophthalmol Vis Sci. 2008 Apr;49(4):1328-32. doi: 10.1167/iovs.07-1115.
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is one of the most common human genetic abnormalities, with a high prevalence in Sardinia, Italy. Evidence indicates that G6PD-deficient patients are protected against ischemic heart and cerebrovascular disease and retinal vein occlusion. The purpose of this study was to assess the frequency of G6PD deficiency in Sardinian patients with nonarteritic anterior ischemic optic neuropathy (NAION) and ascertain whether G6PD deficiency may offer protection against NAION.
Erythrocyte G6PD activity was determined by using a quantitative assay in 140 patients with NAION and 280 age- and gender-matched comparison patients. Conditional logistic regression models were used to investigate the association between G6PD deficiency and NAION.
G6PD deficiency was found in 7 (5%) patients with NAION and 34 (12.1%) control subjects. Differences between cases and controls were statistically significant (P = 0.02). Conditional logistic regression analysis, including as covariates G6PD deficiency, hypertension, diabetes, and hypercholesterolemia, revealed that G6PD deficiency was significantly associated with decreased risk for NAION (odds ratio [OR] = 0.4, 95% confidence interval [CI] = 0.17-0.94, P = 0.035). Conditional logistic regression analyses, including systolic or diastolic blood pressure and plasma glucose and cholesterol levels confirmed that G6PD deficiency was associated with a decreased risk for NAION, but the ORs were not significant at the 0.05 significance level (P = 0.085 and P = 0.071). Models including gender x G6PD deficiency interaction disclosed that gender was not an effect modifier of G6PD deficiency (P > 0.20).
The frequency of G6PD deficiency in patients with NAION was significantly lower than expected. Results suggest that G6PD-deficient patients in the Sardinian population have a significantly decreased risk of having NAION.
葡萄糖-6-磷酸脱氢酶（G6PD）缺乏症是人类最常见的遗传异常之一，在意大利撒丁岛的患病率很高。有证据表明，G6PD缺乏症患者对缺血性心脏病、脑血管疾病和视网膜静脉阻塞具有保护作用。本研究的目的是评估撒丁岛非动脉性前部缺血性视神经病变（NAION）患者中G6PD缺乏症的发生率，并确定G6PD缺乏症是否可以预防NAION。
采用定量分析法测定140例NAION患者和280例年龄及性别匹配的对照患者的红细胞G6PD活性。使用条件逻辑回归模型研究G6PD缺乏症与NAION之间的关联。
在140例NAION患者中有7例（5%）存在G6PD缺乏，而在280例对照者中有34例（12.1%）存在G6PD缺乏。病例组与对照组之间的差异具有统计学意义（P = 0.02）。将G6PD缺乏症、高血压、糖尿病和高胆固醇血症作为协变量的条件逻辑回归分析显示，G6PD缺乏症与NAION风险降低显著相关（比值比[OR] = 0.4，95%置信区间[CI] = 0.17 - 0.94，P = 0.035）。包括收缩压或舒张压以及血糖和胆固醇水平的条件逻辑回归分析证实，G6PD缺乏症与NAION风险降低相关，但在0.05显著性水平时OR值不显著（P = 0.085和P = 0.071）。包含性别×G6PD缺乏症相互作用的模型显示，性别不是G6PD缺乏症的效应修饰因素（P > 0.20）。
NAION患者中G6PD缺乏症的发生率显著低于预期。结果表明，撒丁岛人群中G6PD缺乏症患者患NAION的风险显著降低。
Zotero 插件