Department of Pathology, University of Mississippi Medical Center, 2500 N. State St., Jackson, MS 39216, USA.
Department of Radiation Oncology, University of Mississippi Medical Center, 2500 N. State St., Jackson, MS 39216, USA.
Molecules. 2021 Feb 23;26(4):1191. doi: 10.3390/molecules26041191.
To date very few promising leads from natural products (NP) secondary metabolites with antiviral and immunomodulatory properties have been identified for promising/potential intervention for COVID-19. Using in-silico docking studies and genome based various molecular targets, and their in vitro anti-SARS CoV-2 activities against whole cell and/or selected protein targets, we select a few compounds of interest, which can be used as potential leads to counteract effects of uncontrolled innate immune responses, in particular those related to the cytokine storm. A critical factor for prevention and treatment of SARS-CoV-2 infection relates to factors independent of viral infection or host response. They include population-related variables such as concurrent comorbidities and genetic factors critically relevant to COVID-19 health disparities. We discuss population risk factors related to SARS-CoV-2. In addition, we focus on virulence related to glucose-6-phosphate dehydrogenase deficiency (G6PDd), the most common human enzymopathy. Review of data on the response of individuals and communities with high prevalence of G6PDd to NP, prompts us to propose the rationale for a population-specific management approach to rationalize design of therapeutic interventions of SARS-CoV-2 infection, based on use of NP. This strategy may lead to personalized approaches and improve disease-related outcomes.
迄今为止，从具有抗病毒和免疫调节特性的天然产物（NP）次生代谢产物中，仅发现了极少数有前景的先导化合物，可用于有希望/潜在干预 COVID-19。我们使用计算机对接研究和基于基因组的各种分子靶标，以及它们针对全细胞和/或选定蛋白靶标的抗 SARS-CoV-2 活性，选择了一些感兴趣的化合物，这些化合物可用作潜在的先导物，以对抗不受控制的先天免疫反应的作用，特别是与细胞因子风暴有关的作用。预防和治疗 SARS-CoV-2 感染的一个关键因素与病毒感染或宿主反应无关的因素有关。其中包括与 COVID-19 健康差异密切相关的并发合并症和遗传因素等与人群相关的变量。我们讨论了与 SARS-CoV-2 相关的人群危险因素。此外，我们还关注与葡萄糖-6-磷酸脱氢酶缺乏症（G6PDd）相关的毒力，G6PDd 是最常见的人类酶病。对具有高 G6PDd 患病率的个体和社区对 NP 反应的数据进行回顾，促使我们提出基于 NP 的 SARS-CoV-2 感染治疗干预措施的合理化设计的人群特定管理方法的基本原理。该策略可能会导致个性化方法并改善与疾病相关的结果。
