Department of Medical, Surgical, and Experimental Sciences, University of Sassari, Sassari, Italy.
Azienda Ospedaliero-Universitaria di Sassari, Sassari, Italy.
Int J Med Sci. 2021 Mar 27;18(10):2239-2244. doi: 10.7150/ijms.53668. eCollection 2021.
To assess the role of complete blood cell count (CBC) dimensional indices and CBC-derived measures in non-arteritic anterior ischemic optic neuropathy (NA-AION). In this retrospective case-control survey, 37 newly diagnosed NA-AION patients and 37 sex- and age-matched cataract controls were enrolled in 2017-2018. On the same day of NA-AION diagnosis, a blood sample was collected and CBC was determined using an automatic blood counter. CBC dimensional indices, such as mean platelet volume (MPV) and red cell distribution width (RDW), and CBC-combined indices, including neutrophil/lymphocyte ratio (NLR), derived NLR [dNLR = neutrophils/(white blood cells - neutrophils)], and platelet/lymphocyte ratio (PLR), were evaluated. Erythrocyte sedimentation rate (ESR) was also measured. Mean platelet count, median MPV, RDW, NLR, and dNLR were 221±48 x 10/L, 8.2 fL (IQR=7.6-8.9), 13% (IQR=12-14.5), 2.50 (IQR=1.77-3.06), and 1.73 (IQR=1.31-2.07) in NA-AION patients and 248±56 x 10/L, 7.60 fL (IQR=7.05-8.25), 12% (IQR=11.6-13), 1.95 (IQR=1.43-2.49) and 1.36 (IQR=1.07-1.69) in controls. NA-AION patients showed significantly lower platelet count (p=0.03) and significantly higher median values of MPV (p=0.01), RDW (p=0.015), NLR (p=0.03), and dNLR (p=0.01). Multivariate logistic regression models disclosed a significant correlation only between higher levels of RDW and NA-AION (p≤0.05). The attributable risk of the association between NA-AION and RDW was 33%. Results suggest that RDW may be somehow involved in the pathogenesis of NA-AION. However, high-quality cohort studies are warranted to confirm whether, or not, an altered RDW may be considered a potential biomarker of this vascular disorder affecting the optic nerve.
评估全血细胞计数 (CBC) 维度指数和 CBC 衍生指标在非动脉炎性前部缺血性视神经病变 (NA-AION) 中的作用。在这项回顾性病例对照研究中，2017 年至 2018 年纳入了 37 例新诊断的 NA-AION 患者和 37 例性别和年龄匹配的白内障对照者。在 NA-AION 诊断的同一天采集血样，并使用自动血细胞计数器测定 CBC。评估了 CBC 维度指数，如平均血小板体积 (MPV) 和红细胞分布宽度 (RDW)，以及 CBC 组合指数，包括中性粒细胞/淋巴细胞比值 (NLR)、衍生 NLR [dNLR = 中性粒细胞/(白细胞-中性粒细胞)] 和血小板/淋巴细胞比值 (PLR)。还测量了红细胞沉降率 (ESR)。NA-AION 患者的平均血小板计数、中位数 MPV、RDW、NLR 和 dNLR 分别为 221±48 x 10/L、8.2 fL（IQR=7.6-8.9）、13%（IQR=12-14.5）、2.50（IQR=1.77-3.06）和 1.73（IQR=1.31-2.07），而对照组分别为 248±56 x 10/L、7.60 fL（IQR=7.05-8.25）、12%（IQR=11.6-13）、1.95（IQR=1.43-2.49）和 1.36（IQR=1.07-1.69）。NA-AION 患者的血小板计数明显较低（p=0.03），MPV（p=0.01）、RDW（p=0.015）、NLR（p=0.03）和 dNLR（p=0.01）的中位数明显较高。多变量逻辑回归模型仅显示较高的 RDW 水平与 NA-AION 之间存在显著相关性（p≤0.05）。NA-AION 和 RDW 之间关联的归因风险为 33%。结果表明，RDW 可能在某种程度上参与了 NA-AION 的发病机制。然而，需要进行高质量的队列研究来证实，改变的 RDW 是否可以被认为是影响视神经的这种血管疾病的潜在生物标志物。
