Seven transmembrane-spanning receptors for free fatty acids as therapeutic targets for diabetes mellitus: pharmacological, phylogenetic, and drug discovery aspects.
作者信息
Costanzi Stefano, Neumann Susanne, Gershengorn Marvin C
机构信息
Laboratory of Biological Modeling, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA.
出版信息
J Biol Chem. 2008 Jun 13;283(24):16269-73. doi: 10.1074/jbc.R800014200. Epub 2008 Apr 2.
Abstract
摘要
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Endocrinology. 2008 May;149(5):2038-47. doi: 10.1210/en.2007-0966. Epub 2008 Jan 17.
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Discovery of novel agonists and antagonists of the free fatty acid receptor 1 (FFAR1) using virtual screening.通过虚拟筛选发现游离脂肪酸受体1（FFAR1）的新型激动剂和拮抗剂。
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