Chambers Ann F
Department of Oncology, University of Western Ontario, London, ON, Canada.
Clin Exp Metastasis. 2009;26(1):61-6. doi: 10.1007/s10585-008-9164-4. Epub 2008 Apr 2.
Tumor metastasis is responsible for most cancer deaths, and can occur after long periods of tumor dormancy. Information learned from experimental studies on tumor metastasis and dormancy is shedding light on mechanisms responsible and possible therapeutic approaches. 'Seed' (the cancer cell) and 'soil' (the microenvironment of the secondary organ) factors contribute to metastatic outcome. This review considers the possibility that various dietary components may affect both 'seed' and 'soil' compartments, thereby influencing the growth of metastases, and discusses an experimental study on dietary genistein that illustrates this concept. While studies on human diet are complex, the possibility that relatively non-toxic dietary intervention strategies could impact on metastasis and patient survival is attractive and worthy of further study in appropriate experimental models of metastasis and tumor dormancy.
肿瘤转移是导致大多数癌症死亡的原因，并且可能在肿瘤长期休眠后发生。从关于肿瘤转移和休眠的实验研究中获得的信息正在揭示其背后的机制以及可能的治疗方法。“种子”（癌细胞）和“土壤”（继发器官的微环境）因素对转移结果有影响。本综述探讨了各种饮食成分可能同时影响“种子”和“土壤”成分，从而影响转移灶生长的可能性，并讨论了一项关于饮食中染料木黄酮的实验研究，该研究阐释了这一概念。虽然关于人类饮食的研究很复杂，但相对无毒的饮食干预策略可能会影响转移和患者生存的可能性很有吸引力，值得在合适的转移和肿瘤休眠实验模型中进一步研究。
