丙泊酚-长链甘油三酯与丙泊酚-长链甘油三酯/中链甘油三酯在注射痛方面的比较。

A comparison of propofol-LCT with propofol-LCT/MCT on pain of injection.

作者信息

Sundarathiti Petchara, Boonthom Nuanjai, Chalacheewa Theerawat, Jommaroeng Porpimon, Rungsithiwan Wanadee

机构信息

Department of Anesthesiology, Ramathibodi Hospital, Faculty of Medicine, Mahidol University, Bangkok 10400, Thailand.

出版信息

J Med Assoc Thai. 2007 Dec;90(12):2683-8.

PMID:18386721

Abstract

BACKGROUND

Propofol-Lipuro 1% is consisting of long-chain triglycerides (LCT) and medium-chain triglycerides (MCT) that have been reported to reduce injection pain.

OBJECTIVE

To compare the incidence and intensity of injection pain with 1% Propofol-LCT with 1% Propofol-LCT/MCT in female populations for minor surgery under total intravenous anesthesia (TIVA).

MATERIAL AND METHOD

One hundred and ten female patients were double-blind randomized into two groups. Group long-chain triglycerdes (L) received 1% propofol-LCT while group long-chain triglycerides/medium-chain triglycerides (L/M) received 1% propofol-LCT/MCT. All patients received no benzodiazepine premedication and fentanyl 1 microg/kg was given 3 minutes before propofol injection. The propofol 1 mg/kg was manually injected at 0.5 mL/sec. The verbal rating score (VRS 0-10) was recorded on pain of injection. VRS > 4 indicates a significant response to pain.

RESULTS

There was a significantly greater incidence and intensity of injection pain in group L compared with group L/M (p < 0.001 and p = 0.013 respectively).

CONCLUSIONS

Propofol-LCT/MCT is superior to propofol-LCT on reducing pain of injection.

摘要

背景

丙泊酚乳剂1%由长链甘油三酯（LCT）和中链甘油三酯（MCT）组成，据报道可减轻注射痛。

目的

比较1%丙泊酚-LCT和1%丙泊酚-LCT/MCT在全静脉麻醉（TIVA）下进行小手术的女性人群中注射痛的发生率和强度。

材料与方法

110例女性患者双盲随机分为两组。长链甘油三酯组（L组）接受1%丙泊酚-LCT，长链甘油三酯/中链甘油三酯组（L/M组）接受1%丙泊酚-LCT/MCT。所有患者术前未使用苯二氮䓬类药物，在注射丙泊酚前3分钟给予1μg/kg芬太尼。以0.5mL/秒的速度手动注射1mg/kg丙泊酚。记录注射痛的视觉模拟评分（VRS 0 - 10）。VRS>4表示对疼痛有明显反应。