Cobo Fernando, Talavera Paloma, Concha Angel
Infectious Pathology Unit, Department of Pathology and Tumour and Tissue Bank, Hospital Universitario Virgen de las Nieves, Granada, Spain.
Int J Surg Pathol. 2008 Apr;16(2):127-36. doi: 10.1177/1066896908314700. Epub 2008 Apr 2.
The purpose of this review is to evaluate case reports of papillary squamous cell carcinoma (PSCC) of the upper aerodigestive tract (UADT) to assess its relationship with human papillomavirus (HPV). The medical literature was searched for case reports of this condition. A total of 115 cases of PSCC were found that described the condition in sufficient detail. HPV detection was performed in only 22 of the 115 cases of PSCC (19%), and 11 of the 22 cases (50%) are related to this virus. The majority of cases related to HPV are produced by low-risk HPV type 6 followed by high-risk HPV type 16. Today, the association of HPV with PSCCs seems unclear because in the majority of patients tests were not performed for the detection of the HPV. This association should be clearly established to make a correct diagnosis and propose the best therapeutic strategies, such as new vaccines.
本综述的目的是评估上消化道（UADT）乳头状鳞状细胞癌（PSCC）的病例报告，以评估其与人类乳头瘤病毒（HPV）的关系。检索医学文献以查找该病症的病例报告。共发现115例PSCC病例，对病情描述足够详细。在115例PSCC病例中，仅22例（19%）进行了HPV检测，其中22例中的11例（50%）与该病毒有关。与HPV相关的大多数病例由低风险的HPV 6型引起，其次是高风险的HPV 16型。如今，HPV与PSCC之间的关联似乎尚不明确，因为大多数患者未进行HPV检测。应明确建立这种关联，以便做出正确诊断并提出最佳治疗策略，如新疫苗。
