Serra A, Caltabiano R, Scalia G, Palmucci S, Di Mauro P, Cocuzza S
Department G.F. Ingrassia, ENT Section, University of Catania, Catania, Italy.
Department G.F. Ingrassia, Section of Anatomic Pathology, University of Catania, Italy.
Acta Otorhinolaryngol Ital. 2017 Aug;37(4):341-345. doi: 10.14639/0392-100X-1281.
Papillary squamous neoplasms of the upper respiratory tract are rare variants of squamous cell carcinomas. They are characterised by an exophytic, papillary growth and generally have favourable prognosis. The tumour has been described in the upper aerodigestive tract. In this context, most common sites of involvement are the larynx and hypopharynx, and rarely the oral cavity and oropharynx. The limited studies and small number of published cases of papillary squamous cell carcinoma of the palatine tonsil led us to make a complete analysis of this tumour by analysing the clinical, histological, radiological, virological and therapeutic aspects that are not always present in the literature. A case of papillary squamous cell carcinoma of the palatine tonsil is reported. The lesion (T2N0M0) was located into the left palatine tonsil that hung towards the oral cavity. Both HPV 16 DNA and E6/E7 mRNA were detected in the lesion. The clinicopathological profile of the neoplasm is presented and a comprehensive review of recent literature was made by analysing all aspects of interest of this neoplasm.
上呼吸道乳头状鳞状肿瘤是鳞状细胞癌的罕见变体。它们的特征是外生性乳头状生长，通常预后良好。该肿瘤已在上呼吸消化道中被描述。在此背景下，最常见的受累部位是喉和下咽，很少累及口腔和口咽。腭扁桃体乳头状鳞状细胞癌的研究有限且已发表病例数量较少，这促使我们通过分析文献中并不总是涵盖的临床、组织学、放射学、病毒学和治疗方面，对该肿瘤进行全面分析。本文报告一例腭扁桃体乳头状鳞状细胞癌病例。病变（T2N0M0）位于向左悬垂至口腔的左侧腭扁桃体。在病变中检测到HPV 16 DNA和E6/E7 mRNA。本文呈现了该肿瘤的临床病理特征，并通过分析该肿瘤各方面的相关要点对近期文献进行了全面综述。
