Brain P F, Simón V M, Martińez M
Biological Sciences, University College of Swansea, Wales, UK.
Neurosci Biobehav Rev. 1991 Winter;15(4):521-6. doi: 10.1016/s0149-7634(05)80143-5.
The effects of a range of antiandrogens and antiestrogens on conflict behaviors in laboratory rats and mice are reassessed in the light of recent studies applying ethophamacological analyses (recording the full spectrum of behaviors) to such investigations. It is argued that any antihostility properties of the antiandrogen cyproterone acetate are largely a consequence of indirect actions on odor communication, whereas antiestrogens (e.g., tamoxifen and CI 680) seem to have more fundamental motivational effects in addition to communicatory actions. A detailed example of the approach is provided in which progesterone (which can be antiandrogenic) is given to rats paired in different ways. The type of pairing has a very substantial effect on the actions seen after treatment, and the ethopharmacological approach generates a better picture of antihormone effect than traditional psychopharmacological tests.
鉴于最近将行为药理学分析（记录行为的全谱）应用于此类研究的相关研究，对一系列抗雄激素和抗雌激素对实验室大鼠和小鼠冲突行为的影响进行了重新评估。有人认为，抗雄激素醋酸环丙孕酮的任何抗敌意特性在很大程度上是对气味交流间接作用的结果，而抗雌激素（如他莫昔芬和CI 680）除了具有交流作用外，似乎还具有更基本的动机效应。文中提供了该方法的一个详细示例，即对以不同方式配对的大鼠给予孕酮（可具有抗雄激素作用）。配对类型对治疗后观察到的作用有非常显著的影响，与传统的精神药理学测试相比，行为药理学方法能更全面地呈现抗激素效应。
