Brain P F, Simon V, Hasan S, Martinez M, Castano D
Biomedical and Physiological Research Group, University College of Swansea, UK.
Int J Neurosci. 1988 Aug;41(3-4):169-77. doi: 10.3109/00207458808990723.
Recent studies suggest that motivations for certain forms of masculine behavior including social aggression are mediated by central estrogen receptors. Two studies using antiestrogens in rodent species were performed. Intact male LH rats were given Tamoxifen or vehicle for 4 or 8 days. The three possible pairings were videotaped for 60 min. Intact male OF1 mice were given CI-680 or vehicle over 25 days. Similar pairings were carried out but some CI-680 or vehicle animals were paired with anosmic opponents. Encounters were videotaped for 10 min. In both experiments evidence was obtained that the antiestrogen markedly reduced time allocated to offense. Any variations in defense were a consequence of the level of attack to which animals were subjected. Neither compound greatly influenced the androgen-dependent sex accessory glands. Antiestrogens consequently have potential as antihostility agents in some forms of attack.
最近的研究表明，包括社会攻击行为在内的某些形式的男性化行为的动机是由中枢雌激素受体介导的。进行了两项在啮齿动物中使用抗雌激素的研究。给完整的雄性LH大鼠服用他莫昔芬或赋形剂，持续4天或8天。对三种可能的配对进行60分钟的录像。给完整的雄性OF1小鼠服用CI-680或赋形剂，持续25天。进行了类似的配对，但一些服用CI-680或赋形剂的动物与嗅觉缺失的对手配对。对相遇情况进行10分钟的录像。在两个实验中都获得了证据，即抗雌激素显著减少了用于攻击的时间。防御方面的任何变化都是动物所遭受攻击程度的结果。两种化合物都没有对雄激素依赖性附属性腺产生很大影响。因此，抗雌激素在某些形式的攻击中具有作为抗敌意药物的潜力。
