Putney James W, Bird Gary S
National Institute of Environmental Health Sciences, NIH, Department of Health and Human Services, PO Box 12233, Research Triangle Park, NC 27709, USA.
J Physiol. 2008 Jul 1;586(13):3055-9. doi: 10.1113/jphysiol.2008.153221. Epub 2008 Apr 3.
Intracellular calcium oscillations have fascinated scientists for decades. They provide an important cellular signal which, unlike most signalling mechanisms, is digitally encoded. While it is generally agreed that oscillations most frequently arise from cyclical release and re-uptake of intracellularly stored calcium, it is becoming increasingly clear that influx of calcium across the plasma membrane also plays a critical role in their maintenance and even in delivering their signal to the correct cellular locus. In this review we will discuss the role played by Ca(2+) entry mechanisms in Ca(2+) oscillations, and approaches to understanding the molecular nature of this Ca(2+) entry pathway.
几十年来，细胞内钙振荡一直吸引着科学家们。它们提供了一种重要的细胞信号，与大多数信号传导机制不同，这种信号是数字编码的。虽然人们普遍认为振荡最常源于细胞内储存钙的周期性释放和重新摄取，但越来越明显的是，钙通过质膜的内流在其维持过程中甚至在将信号传递到正确的细胞位点方面也起着关键作用。在这篇综述中，我们将讨论钙离子进入机制在钙离子振荡中所起的作用，以及理解这种钙离子进入途径分子本质的方法。
