Parekh Anant B
Department of Physiology, Anatomy and Genetics, Sherrington Building, Parks Road, Oxford, UK.
Cell Calcium. 2007 Aug;42(2):111-21. doi: 10.1016/j.ceca.2007.02.012. Epub 2007 Apr 18.
Store-operated CRAC channels, which are activated by the emptying of the endoplasmic reticulum Ca(2+) stores, are an important and widespread route for triggering rises in cytoplasmic Ca(2+). The cellular responses that are activated in response to Ca(2+) entry through CRAC channels are being dissected out, and recent evidence has established that CRAC channels can induce both short-term (safeguarding the Ca(2+) content of the endoplasmic reticulum, maintenance of cytoplasmic Ca(2+) oscillations, enzyme activation, secretion) and long-term (gene expression) changes in cells. CRAC channel activation is therefore capable of evoking a range of temporally distinct responses, highlighting the versatility of this ubiquitous Ca(2+) entry pathway.
由内质网Ca(2+)储存排空激活的储存性钙释放激活钙通道（CRAC通道），是触发细胞质Ca(2+)升高的重要且广泛存在的途径。通过CRAC通道进入细胞的Ca(2+)所激活的细胞反应正在被剖析出来，最近的证据表明，CRAC通道可诱导细胞发生短期（保护内质网的Ca(2+)含量、维持细胞质Ca(2+)振荡、酶激活、分泌）和长期（基因表达）变化。因此，CRAC通道激活能够引发一系列时间上不同的反应，突出了这种普遍存在的Ca(2+)进入途径的多功能性。
