Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, United States.
Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, United States.
Cell Calcium. 2019 May;79:1-10. doi: 10.1016/j.ceca.2019.01.005. Epub 2019 Feb 8.
Cardiorespiratory disease, which includes systemic arterial hypertension, restenosis, atherosclerosis, pulmonary arterial hypertension, asthma, and chronic obstructive pulmonary disease (COPD) are highly prevalent and devastating diseases with limited therapeutic modalities. A common pathophysiological theme to these diseases is cellular remodeling, which is contributed by changes in expression and activation of ion channels critical for either excitability or growth. Calcium (Ca) signaling and specifically ORAI Ca channels have emerged as significant regulators of smooth muscle, endothelial, epithelial, platelet, and immune cell remodeling. This review details the dysregulation of ORAI in cardiorespiratory diseases, and how this dysregulation of ORAI contributes to cellular remodeling.
心血管疾病包括系统性动脉高血压、再狭窄、动脉粥样硬化、肺动脉高血压、哮喘和慢性阻塞性肺疾病（COPD），这些疾病患病率高、破坏性强，治疗方法有限。这些疾病的一个共同病理生理主题是细胞重构，这是由对于兴奋性或生长至关重要的离子通道的表达和激活变化引起的。钙（Ca）信号传导，特别是 ORAI Ca 通道，已成为平滑肌、内皮、上皮、血小板和免疫细胞重构的重要调节剂。本文详细介绍了 ORAI 在心血管疾病中的失调，以及 ORAI 的这种失调如何导致细胞重构。
