Barone P, Mauro L, Leonardi S, Ienna M, Giammanco Bilancia G, Falcidia E, Musumeci S
Department of Pediatrics, University of Catania, Italy.
Acta Paediatr Jpn. 1991 Aug;33(4):455-8. doi: 10.1111/j.1442-200x.1991.tb02571.x.
An extensive vaccination program to be used in highly endemic areas is the main strategy against the spreading of hepatitis B. The purpose of this study was the evaluation of the immune response to the recombinant HB vaccine administered singly or at the same time as other compulsory vaccines anti-diphtheria, anti-tetanus and oral anti-polio. Evidence was found of the serological efficacy both of HB vaccine and compulsory vaccines with a percentage of seroconversion of 100%. However, the infants who received HB vaccine at birth and at the age of 1 month had titers of antiHBs higher than the infants who received HB vaccine at birth and at 3 months. No difference in antibody levels of compulsory vaccines was observed among the study groups and the controls who received only compulsory vaccines. Our results suggest that HB vaccination must be encouraged and pursued in all newborns.
在高流行地区开展广泛的疫苗接种计划是对抗乙型肝炎传播的主要策略。本研究的目的是评估单独接种重组乙肝疫苗或与其他强制性疫苗（抗白喉、抗破伤风和口服抗脊髓灰质炎疫苗）同时接种时的免疫反应。发现乙肝疫苗和强制性疫苗均具有血清学效力，血清转化率为100%。然而，出生时和1月龄接种乙肝疫苗的婴儿的抗-HBs滴度高于出生时和3月龄接种乙肝疫苗的婴儿。在研究组和仅接种强制性疫苗的对照组之间，未观察到强制性疫苗抗体水平的差异。我们的结果表明，必须鼓励并推行对所有新生儿进行乙肝疫苗接种。
