[Immune response and reactions to simultaneous administration of hepatitis B vaccine with routine vaccine in children. I. Immune response and reactions to simultaneous administration of DPT, TOPV and hepatitis B vaccine].

This paper reports the result of the immune response and reactions to simultaneous administration of DPT, TOPV and hepatitis B vaccine. 180 children (0-5 months of age) were divided into three groups. Group one was vaccinated with hepatitis B vaccine alone, group two was vaccinated with DPT, TOPV vaccine, and group three was vaccinated with hepatitis B vaccine, DPT and TOPV vaccine simultaneously. The result of the immune response to the combination of hepatitis B with DPT, TOPV vaccines were similar to that observed after immunization with each vaccine alone. The general reactions of all vaccines were mild, no significant difference between each group was noted. The study demonstrated that children can be immunized with hepatitis B vaccine and DPT, TOPV vaccines simultaneously.