Sierra-Johnson Justo, Undén Anna-Lena, Linestrand Madeleine, Rosell Magdalena, Sjogren Per, Kolak Maria, De Faire Ulf, Fisher Rachel M, Hellénius Mai-Lis
Department of Medicine, Atherosclerosis Research Unit, Karolinska Institutet, Stockholm, Sweden.
Obesity (Silver Spring). 2008 Jun;16(6):1302-7. doi: 10.1038/oby.2008.203. Epub 2008 Apr 3.
Skipping meals is a common practice in our current society; however, it is not clear whether eating meals regularly is associated with the metabolic syndrome.
Our aim was to assess the association of eating meals regularly with parameters of the metabolic syndrome and insulin resistance in a representative population-based cohort of 60-year-old men and women.
A population-based cross-sectional study of 3,607 individuals (1,686 men and 1,921 women), aged 60 years, was conducted in Stockholm County, Sweden. Medical history, socioeconomic factors, and lifestyle data were collected by a questionnaire and a medical examination, which included laboratory tests.
Of the subjects who were regular eaters, 20% fulfilled the criteria for the metabolic syndrome vs. 27% of subjects who were irregular eaters (P < 0.0001). The adjusted odds ratio (OR) for having the greatest number of components of the metabolic syndrome in subjects who were regular eaters was 0.27 (95% confidence interval (CI), 0.13-0.54) using subjects who did not fulfill any criteria for the metabolic syndrome as a reference group. Eating meals regularly was also inversely related to insulin resistance (OR, 0.68 (95% CI, 0.48-0.97)) and to gamma-glutamyl transferase (OR, 0.52 (95% CI, 0.33-83)) after full adjustment.
Eating meals regularly is inversely associated to the metabolic syndrome, insulin resistance and (high) serum concentrations of gamma-glutamyl transferase. These findings suggest that eating meals irregularly may be part of several potential environmental risk factors that are associated with the metabolic syndrome and may have future implications in giving dietary advice to prevent and/or treat the syndrome.
在当今社会，不吃正餐是一种常见现象；然而，规律进餐是否与代谢综合征相关尚不清楚。
我们的目的是在一个具有代表性的60岁男性和女性人群队列中，评估规律进餐与代谢综合征参数及胰岛素抵抗之间的关联。
在瑞典斯德哥尔摩县对3607名60岁个体（1686名男性和1921名女性）进行了一项基于人群的横断面研究。通过问卷调查和包括实验室检查在内的医学检查收集病史、社会经济因素和生活方式数据。
规律进餐的受试者中，20%符合代谢综合征标准，而非规律进餐的受试者中这一比例为27%（P<0.0001）。以未符合任何代谢综合征标准的受试者作为参照组，规律进餐的受试者出现最多代谢综合征组分的调整后优势比（OR）为0.27（95%置信区间（CI），0.13 - 0.54）。在完全调整后，规律进餐还与胰岛素抵抗呈负相关（OR，0.68（95%CI，0.48 - 0.97））以及与γ-谷氨酰转移酶呈负相关（OR，0.52（95%CI，0.33 - 0.83））。
规律进餐与代谢综合征、胰岛素抵抗以及（高）血清γ-谷氨酰转移酶浓度呈负相关。这些发现表明，不规律进餐可能是与代谢综合征相关的几种潜在环境危险因素之一，并且在提供预防和/或治疗该综合征的饮食建议方面可能具有未来意义。
