You Q S, Xu L, Jonas J B
Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Eye (Lond). 2008 May;22(5):728-9. doi: 10.1038/eye.2008.87. Epub 2008 Apr 4.
To determine the prevalence of tilted optic discs and their associations with ocular and general parameters.
The Beijing Eye Study included 4439 subjects out of 5324 subjects invited to participate (response rate 83.4%) with an age of 40+ years. The present investigation consisted of 4324 (97.4%) subjects for whom readable fundus photographs of at least one eye were available. The main outcome parameter was the presence of tilted optic discs defined as small discs with an oblique orientation and oval disc shape without signs of pathology in eyes without high myopia (defined as >-8 D).
Tilted optic discs were detected in 31 eyes (0.36; 95% confidence interval: 0.23, 0.49%) of 23 patients (16 women). Tilted discs were associated with myopia (-6.59+/-0.68 D vs -0.60+/-0.02 D, P<0.001), astigmatism (1.55+/-0.24 D vs 0.59+/-0.01 D, P<0.001), lower best corrected visual acuity (P<0.001), visual field defects (P<0.001), and small optic disc area (P<0.001).
Tilted optic discs are present in about four out of 1000 eyes of adult Chinese in Northern China. They are associated with medium myopia, astigmatism, decreased visual acuity, and visual field defects.
确定倾斜视盘的患病率及其与眼部和全身参数的关联。
北京眼病研究纳入了5324名受邀参与者中的4439名（应答率83.4%），年龄在40岁及以上。本次调查包括4324名（97.4%）受试者，他们至少有一只眼睛的眼底照片可读。主要观察指标是倾斜视盘的存在，定义为在无高度近视（定义为>-8D）的眼中，视盘小、呈倾斜方向且为椭圆形，无病理迹象。
在23例患者（16名女性）的31只眼中检测到倾斜视盘（0.36；95%置信区间：0.23，0.49%）。倾斜视盘与近视（-6.59±0.68D对-0.60±0.02D，P<0.001）、散光（1.55±0.24D对0.59±0.01D，P<0.001）、较低的最佳矫正视力（P<0.001）、视野缺损（P<0.001）和小视盘面积（P<0.001）相关。
在中国北方成年中国人中，约每1000只眼睛中有4只存在倾斜视盘。它们与中度近视、散光、视力下降和视野缺损有关。
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