猿猴空泡病毒40（SV40）转化对3T3小鼠胚胎成纤维细胞染色体蛋白的影响。
The effect of SV40 transformation on the chromosomal proteins of 3T3 mouse embryo fibroblasts.
作者信息
Krause M O, Noonan K D, Kleinsmith L J, Stein G S
出版信息
Cell Differ. 1976 Jul;5(2):83-96. doi: 10.1016/0045-6039(76)90002-6.
PMID:183894
Abstract
The composition and metabolism of chromosomal proteins-histones and nonhistones chromosomal proteins-were examined in normal and SV40 transformed 3T3 mouse cells. Variations were observed, many of which were similar to those previously reported for normal and SV40 transformed W138 human diploid fibroblasts. The possible implications of these viral induced changes in the protein component of the genome for the phenotypic modifications which occur in transformed cells are discussed.
摘要
在正常和SV40转化的3T3小鼠细胞中研究了染色体蛋白（组蛋白和非组蛋白染色体蛋白）的组成和代谢。观察到了一些变化，其中许多变化与先前报道的正常和SV40转化的W138人二倍体成纤维细胞中的变化相似。本文讨论了这些病毒诱导的基因组蛋白质成分变化对转化细胞中发生的表型修饰的可能影响。
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