Lobo Otilia J F, Banji David, Annamalai A R, Manavalan R
Department of Pharmacology, Siddaganga College of Pharmacy, Tumkur-572102, Karnataka.
Pak J Pharm Sci. 2008 Apr;21(2):195-9.
The occurrence of aggression for prolonged periods of time could have a hazardous impact on the health and social wellbeing of the individual. Aggression can ensue due to exposure to an intimidating situation. Aggression is prominently seen when a disturbance occurs in the fine balance of neurotransmitters such as 5-hydroxytryptamine, gamma- aminobutyric acid, dopamine and their receptor subtypes. The present study investigated the ability of 100 and 200mg/kg of aqueous extract of Eclipta alba to circumvent aggression. Foot shock induced aggression and water competition test were utilized as models for screening of antiaggressive activity. Eclipta alba significantly minimized dominance (p<0.05) which is correlated to the level of aggression particularly with 200mg/kg in the water competition test. A tangible behavioral submission was observed with 100 and 200mg/kg and of Eclipta alba in the foot shock induced test.
长时间的攻击行为可能会对个体的健康和社会福祉产生有害影响。接触到令人生畏的情况可能会引发攻击行为。当5-羟色胺、γ-氨基丁酸、多巴胺及其受体亚型等神经递质的微妙平衡受到干扰时，攻击行为就会显著出现。本研究调查了100毫克/千克和200毫克/千克的旱莲草水提取物规避攻击行为的能力。足部电击诱导攻击行为和水竞争试验被用作筛选抗攻击活性的模型。旱莲草显著降低了优势地位（p<0.05），这与攻击水平相关，尤其是在水竞争试验中200毫克/千克的剂量。在足部电击诱导试验中，观察到100毫克/千克和200毫克/千克的旱莲草有明显的行为顺从。
