Yadav Navneet Kumar, Arya Rakesh Kumar, Dev Kapil, Sharma Chetan, Hossain Zakir, Meena Sanjeev, Arya K R, Gayen J R, Datta Dipak, Singh R K
Toxicology Division, CSIR-Central Drug Research Institute, Lucknow 226031, India.
Biochemistry Division, CSIR-Central Drug Research Institute, Lucknow 226031, India.
Oxid Med Cell Longev. 2017;2017:9094641. doi: 10.1155/2017/9094641. Epub 2017 Jan 31.
As per WHO estimates, 80% of people around the world use medicinal plants for the cure and prevention of various diseases including cancer owing to their easy availability and cost effectiveness. has long been used in Ayurveda to treat liver diseases, eye ailments, and hair related disorders. The promising medicinal value of prompted us to study the antioxidant, nontoxic, and anticancer potential of its alcoholic extract. In the current study, we evaluated the cytotoxic and antioxidant effect of the alcoholic extract of (AEEA) in multiple cancer cell lines along with control. We have also evaluated its effect on different toxicity parameters. Here, we found that AEEA was found to be most active in most of the cancer cell lines but it significantly induced apoptosis in human breast cancer cell lines by disrupting mitochondrial membrane potential and DNA damage. Moreover, AEEA treatment inhibited migration in both MCF 7 and MDA-MB-231 cells in a dose dependent manner. Further, AEEA possesses robust antioxidant activity along with high total phenolic and flavonoid contents. In summary, our results indicate that has enormous potential in complementary and alternative medicine for the treatment of cancer.
根据世界卫生组织的估计，由于药用植物易于获取且成本效益高，全球80%的人使用药用植物来治疗和预防包括癌症在内的各种疾病。 长期以来一直被用于阿育吠陀医学来治疗肝脏疾病、眼部疾病和与头发相关的疾病。 的潜在药用价值促使我们研究其酒精提取物的抗氧化、无毒和抗癌潜力。在当前的研究中，我们评估了 酒精提取物（AEEA）对多种癌细胞系以及对照的细胞毒性和抗氧化作用。我们还评估了其对不同毒性参数的影响。在这里，我们发现AEEA在大多数癌细胞系中最具活性，但它通过破坏线粒体膜电位和DNA损伤在人乳腺癌细胞系中显著诱导凋亡。此外，AEEA处理以剂量依赖的方式抑制MCF 7和MDA - MB - 231细胞的迁移。此外，AEEA具有强大的抗氧化活性以及高总酚和黄酮含量。总之，我们的结果表明 在补充和替代医学中治疗癌症具有巨大潜力。
