Davidson M B, Gerschenson L E
Horm Metab Res. 1977 May;9(3):195-9. doi: 10.1055/s-0028-1093535.
The ability of insulin and proinsulin to stimulate tyrosine transaminase in dexamethasone-treated cultured rat liver cells was compared. Insulin increased this enzyme whereas proinsulin was seemingly without effect. Since proinsulin was not degraded by these cells, failure of stimulation of hepatic tyrosine transaminase could not be due to rapid destruction of the prohormone. This is the first demonstration of an action of insulin that cannot be duplicated by proinsulin.
比较了胰岛素和胰岛素原对用地塞米松处理的培养大鼠肝细胞中酪氨酸转氨酶的刺激能力。胰岛素可增加这种酶的活性，而胰岛素原似乎没有作用。由于这些细胞不会降解胰岛素原，因此肝酪氨酸转氨酶刺激失败并非由于激素原的快速破坏所致。这是胰岛素的一种作用首次被证明不能被胰岛素原复制。
